Research Article - Biomedical Research (2017) Volume 28, Issue 22

Comparison of short- and long-term therapeutic effects of laparoscopic and open-type hepatectomy for primary hepatic carcinoma

Objective: To compare short- and long-term therapeutic effects of laparoscopic and open-type hepatectomy for primary hepatic carcinoma.

Method: Forty patients with primary hepatic carcinoma in our hospital were recruited from January 2013 to August 2014. They were divided into two groups, namely, laparoscopic and open-type, with 20 cases in each group, and their short- and long-term therapeutic effects were then compared.

Results: Intra-operative bleeding quantity, length of operative incision, extubation time, eating time, and length of stay in the laparoscopic group were lesser than those in the open-type group; operation time was more than that in the open-type group (P<0.05). Comparative differences in pre-operative liver functions, such as Aspartate Transaminase (AST) and Alanine Transaminase (ALT), between the two groups did not have statistical significance (P>0.05). Three days after the operation, AST and ALT levels of both groups increased to peak values (P<0.05). However, 10 days after operation, the decrease in AST and ALT levels was obviously faster in the laparoscopic group than in the open-type group (P<0.05); the occurrence rate of post-operative complications was obviously lesser in the laparoscopic group than in the open-type group (P<0.05); comparative differences in three-year recurrence and survival rates between the two groups did not have statistical significance (P>0.05).

Conclusion: Laparoscopic hepatectomy provided several advantages, such as small trauma, minor influence on liver function, and few post-operative complications, for patients with primary hepatic carcinoma; however, its post-operative three-year survival rate was equivalent to that of open-type operation, indicating its high therapeutic value.

Author(s): Kun He, Ze-Min Hu, Jia-Hou Ruan, Dong-Dong Huang, Xue-Yi Gong, Qi-Jie Luo

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