Biomedical Research

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- Biomedical Research (2011) Volume 22, Issue 2

Comparative study of trace elements and serum ceruloplasmin level in normal and pre-eclamptic pregnancies with their cord blood

The aim of the present study is to assess the comparison of trace elements and serum ceru-loplasmin level in normal and pre-eclamptic pregnancies with their cord blood. Pregnancy is associated with increased demand of all the micronutrients like Iron, Copper, Zinc, Vit B12, Folic acid and Ascorbic acid. The pregnant women were admitted in maternity ward, De-partment of Obstetric and Gynecology, Command Hospital, Pune. The study group com-prised of 61 pregnant women and their newborns. Venous blood (5 ml.) was collected from mother at the time of delivery and cord blood (10 ml.) was taken from maternal end of um-bilical cord. Of 61 pregnant women, 14 were pre-eclamptic and 47 were normal pregnant women. In normal pregnancy, the copper & ceruloplasmin concentration were statistically significantly increased (p<0.01) in maternal blood as compared to cord blood. Serum iron and zinc concentration were observed significantly raised (p<0.01) in cord blood compared to maternal blood. Similar results were found in pre-eclamptic pregnancies. The significant difference (p<0.001) was observed in all biochemical parameters between maternal and cord blood pre-eclamptic pregnancies. On comparison of the normal and pre-eclamptic preg-nancy, the serum iron significantly increased (p<0.01) in normal pregnancy than pre-eclamptic, but no statistically significant variations were observed in serum zinc, copper and ceruloplasmin concentration. Our study infers that iron is the most important micronutrient and it should be supplemented as a daily requirement in pregnant women. Ceruloplasmin can be used as a diagnostic measurement in pregnancy period.

Author(s): Savita Rathore, Ashish Gupta, Hitender Singh Batra, Rajkumari Rathore

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