Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

- Biomedical Research (2015) Volume 26, Issue 3

Changes in serum cytokine levels in hand-foot-and-mouth disease.

The aim of this study was to investigate changes in serum cytokine levels in children with handfoot- and-mouth disease (HFMD) and their clinical significance. Clinical data from 241 children with HFMD, hospitalized between May 2012 and January 2013, were analyzed retrospectively. Patients were divided into a normal case group (n=107) and a severe case group (n=134), and the clinical features of the children were summarized. Concurrently, a etiological examination was performed, and the levels of 5 cytokines were measured: interleukin (IL)-2, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ. There was no significant difference in the age, sex ratio, length of hospital stay, and the highest temperature between groups. IL-2, IL- 6, IL-10, and TNF-α levels were significantly higher (P<0.05) in the severe case group than in the normal case group; however, there was no significant difference in IFN-γ levels between the 2 groups. Elevated cytokine levels measured in severe cases of HFMD, suggesting that cytokinerelated inflammation and anti-inflammatory responses might be involved in the development of severe HFMD.

Author(s): Tong-Zeng Li, Tai-Yi Jiang, Lian-Chun Liang

Abstract Full Text PDF

Get the App

https://pmasites.com