Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

Research Article - Biomedical Research (2018) Volume 29, Issue 13

Brn-3a and Brn-3b are differentially expressed in recurrent respiratory papillomatosis associated to HPV-6 and HPV-11 infection

Brn-3a and Brn-3b are transcription factors expressed mainly in somatosensory neurons during embryonic stage; but they are absent in adulthood. Both share the same DNA binding site with an antagonist effect. Brn-3a expression has been reported 300 fold increased in Cervical Intraepithelial Neoplasia grade 3 (CIN3) compared with normal cervix tissue; some studies suggest that Brn-3a may increase the expression of HPV onco-proteins E6 and E7 by interaction with the promoter region of some high risk HPV genotypes. In this study, we analyzed the expression of Brn-3a and Brn-3b in laryngeal tissue biopsies from patients with Recurrent Respiratory Papillomatosis (RRP) and in volunteers´ health tissue. HPV was detected in all RRP samples and only HPV-6 and HPV-11 were detected in the samples of RRP. Brn-3a was expressed in 87% of the samples and Brn-3b in 45% coexpressed with Brn-3a. Brn-3a is expressed in laryngeal papillomas of patients with RRP diagnostic; but not in normal laryngeal tissue. The most of the samples expresses Brn-3a and only half weakly expresses Brn-3b; which suggests that the antagonist role of Brn-3b over Brn-3a is absent in this process.

Author(s): Sanchez-Gonzalez Maria Teresa, Marino-Martinez Ivan Alberto, Trevino-Gonzalez Jose Luis, Ponce-Camacho Marco Antonio, Santos-Lartigue Ramiro, Martinez-Vite Raul, Villagomez-Ortiz Vicente Jose, Ortiz-Lopez Rocio, Rojas-Martinez Augusto

Abstract Full Text PDF

Get the App