Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2017) Volume 28, Issue 19

Association of IL-18 genetic polymorphisms and haplotypes with breast cancer risk in a Chinese population

Objective: We performed a case-control study to evaluate the role of IL-18-07C/A (rs1946518) and -137G/C (rs187238) polymorphisms in the development of breast cancer.

Methods: A total of 305 breast cancer patients and 305 healthy controls were recruited between May 2015 and May 2016. The genotyping of IL-18 -607C/A and -137G/C polymorphisms was carried out by an iPlex GOLD SNP genotyping analysis using the Sequenom MassARRAY® System.

Results: We observed that the CC genotype of IL-18 -607C/A was associated with breast cancer risk (OR=1.80, 95%CI=1.06-3.07), when compared with the CC+CA genotype. The CC genotype of IL-18 -137G/C had a 2.90 fold risk of breast cancer as compared to the CC genotype, and the CC genotype also showed an increased risk of breast cancer compared with the GG+GC genotype (OR=2.94, 95%CI=1.41-6.11). A completely linkage disequibrium was found between IL-18 rs1946518 and rs187238 (D’=1.00, r2=0.19). The A-C (OR=1.52, 95%CI=1.11-2.08) and C-G (OR=0.79, 95%CI=0.62-0.99) haplotypes were associated with breast cancer risk.

Conclusion: We found that IL-18 -607C/A and -137G/C polymorphisms and haplotypes contribute to increase the breast cancer risk.

Author(s): Yue Zhao, Shuai Wang, Zhenchao Zhang, Chuan Qin, Xianjun Yang, Qing Xie

Abstract Full Text PDF

Get the App