Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

Research Article - Biomedical Research (2017) Volume 28, Issue 21

Association of glutathione S-transferase P1 polymorphism and endometrial cancer risk in a Chinese population

The aim of this study was to investigate the relationship between glutathione S-transferase P1 (GSTP1) genetic polymorphism and endometrial cancer risk in a Chinese population. A total of 217 women diagnosed with endometrial cancer and 200 controls were retained for the present analysis. GSTP1 null genotype was significantly associated with endometrial cancer risk (OR=1.56, 95% CI 1.07-2.29, P=0.02). To further assess the effects of GSTP1 genetic polymorphism on clinical characteristics, stratification analyses were conducted. No significant association was found between GSTP1 polymorphism and BMI (OR=1.35, 95% CI 0.70-2.61, P=0.36), staging (OR=1.14, 95% CI 0.67-1.97, P=0.62) and grading (OR=0.93, 95% CI 0.52-1.57, P=0.74). In conclusion, the GSTP1 polymorphism was significantly associated with an increased risk of endometrial cancer.

Author(s): Ping Liu

Abstract Full Text PDF

Get the App

best replica reviews