Current Pediatric Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44 1400 530055

Research Article - Current Pediatric Research (2019) Volume 23, Issue 2

Association between sepsis induced acute kidney injury with shock and length of stay in critically ill pediatric patients

Introduction: Sepsis induced AKI is reversible increase in serum creatinine levels or nitrogen metabolism products and the inability of the kidneys to regulate fluid and electrolytes to a state of body homeostasis caused by sepsis. This study aimed to find out relationship between sepsis-induced AKI and shock and length of stay in Pediatric Intensive Care Unit (PICU).

Methods: This prospective cohort study was conducted in PICU from November 2017 to October 2018. A total of 90 sepsis patients were included. The diagnostic of septic shock based on International Pediatric Sepsis Consensus 2015. Kidney function examination and urine production every 8 hours was done to determine whether or not Acute Kidney Injury present. Patient were observed until the outcome occurred; either septic patient become shock or not and how long they were treated in PICU.

Results: Result of 90 sepsis patients, 36 patients (40%) become sepsis-induced AKI. Chi Square analysis found significant differences in the incidence of shock in sepsis-induced AKI patient with p=0.00 with OR 4.37, 95% CI 1,689 - 11.33. Sepsis patient with AKI will undergo longer treatment in PICU if compared to sepsis patients without AKI. However, Mann-Whitney test showed not significant (p=0.25).

Conclusion: Incidence of sepsis-induced AKI in this cohort of children was 40%, and shock severity in patients with sepsis induced-AKI was higher than those with sepsis without AKI, and there was no difference in length of stay between sepsis patients with AKI and without AKI.

Author(s): Idham Jaya Ganda*, Karjana, Dasril Daud

Abstract Full Text PDF

Get the App