Journal of Pharmaceutical Chemistry & Chemical Science

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Mini Review - Journal of Pharmaceutical Chemistry & Chemical Science (2022) Volume 6, Issue 2

Anti-polyethylene glycol IgG intergenerational inheritance feature.

Anti-polyethylene glycol (PEG) antibodies (APAs) are common in healthy adults, according to several studies. Anti-PEG immunoglobulin (IgG) prevalence is adversely linked with age. Wistar rats were utilized as a model organism to see if APAs in the parents can influence the generation of antibodies in their offspring. The parental rats were matched in cages after being pre-stimulated with blank PEGylated Nano emulsions (PE) to trigger APAs production. Antibodies were found in the parents and offspring utilizing an enzyme-linked immunosorbent test. Immunoglobulin in the parents caused considerable anti-PEG IgG positivity in their kids, demonstrating that antiPEG IgG is passed down through generations. Furthermore, anti-PEG IgG in the offspring rats may bind to PE and speed up its removal from the bloodstream.

Author(s): Brijeshi Patel*

Abstract Full Text PDF

Get the App