+1 (202) 780-3397MONOHYDRIC PHENOL IMPACT ON THE STATE OF CEREBRAL BLOOD FLOW AND COGNITIVE FUNCTIONS OF CHILDREN
Joint Event on 2nd International Conference on CELL AND GENE THERAPY & 2nd World Congress on PUBLIC HEALTH, EPIDEMIOLOGY AND NUTRITION
April 15-16, 2019 | Milan, Italy
Alfiia I Aminova
Sechenov First Moscow State Medical University, Russia
Keynote : Arch Gen Intern Med
Abstract:
Introduction: It is known that among the factors which induce the development
of cerebrovascular disorders are hypoxia and the impact of toxic
substances on the central nervous system, phenol and its derivatives (cresols)
belong to the group of highly hazardous substances (category 2). The main
sources of anthropogenic phenols are chemicals such as coke and petrochemicals,
textiles, pulp and paper industry. Phenols and cresols are able to
accumulate in the brain parenchyma. This may lead to the development of
cerebrovascular disorders. The objective of this study is to evaluate the patterns
of cerebral haemodynamics and cognitive function impairments for
children with vegetovascular dystonia associated with exposure of monohydric
phenols.
Conclusions: Thus, dysfunction associated with aerogenic phenol and cresol
influence is characterized the linear velocity of the blood flow in the cerebral
arteries, a low level of audio-verbal memory, the overall mental development
and a high degree of anxiety are the effect markers of conditions of phenol
and cresol influence. Identified patterns of cognitive, behavioural status and
cerebral haemodynamics are recorded on the background of marker deviations
of homeostatic parameters concerning phenol in children in the form
of increased level of regulatory hormones and cholinergic neurotransmitters
(adrenocorticotropic hormone, cortisol, serotonin and cGMP), increased lipid
peroxidation products, activation and consequent depletion of antioxidant
blood activity and an increase of MDA concentration. Submitted patterns
of cerebral blood flow and cognitive and behavioural functions can be used
as an additional criterion of dysfunctions of the central humoral- metabolic
mechanisms in children with influence of monohydric phenols.
Biography:
Alfiia I Aminova is a Paediatric faculty from Sechenov First Moscow State Medical University, Russia. She is the Head of the clinic Federal Research Center for Medico-Prophylactic Technologies for Health Risk Management during 2009-2013. She is working as a Lecturer at two different Universities. Her highest qualification is in Paediatrics and Gastroenterology. Her area of scientific interests is children’s gastroenterology, ecology, sports medicine and rehabilitation. She has more than 300 publications, including 127 in peer-reviewed journals and she is the author of seven inventions, two monographs and more than 30 manuals for doctors.
E-mail: aminova62@yandex.ru
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