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Pediatric Pulmonary Actinomycosis: Case Report and Review of Literature

Albar Rawia F1, Alqurashi Mansour A2, Alfaidi Ahmed M3*, Alesa Abdullah A3, Fatani Abrar N3

1Assistant Professor, Consultant General Pediatrics and Pediatric Pulmonology, Section Head of General Pediatrics, KAMC, KSAUHS, Jeddah, Saudi Arabia

2Section Head and Consultant Neonatologist, Department of General Pediatrics, KAMC, Jeddah, Saudi Arabia

3Department of General Pediatrics, Ministry of National Guard – Health Affairs, King Abdulaziz Medical City, Westren Region, Jeddah, Kingdom of Saudi Arabia

*Corresponding Author:
Ahmed Mohammed Alfaidi
Department of General Pediatrics
Ministry of National Guard – Health Affairs
King Abdulaziz Medical City, Westren Region, Jeddah
Kingdom of Saudi Arabia
Tel: +966506028863
E-mail: [email protected]
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Abstract

Pulmonary actinomycosis is a rare infection that usually needs biopsy confirmation to be diagnosed. They usually present with chest wall mass or with chest pain. Upon investigation, many have worrisome imaging results that usually represent a mass with some periosteal destruction. Patients can fully recover from this infection if the appropriate treatment was not delayed. A 12 years old boy presents to our department with a one month history of chest wall mass and one week of chest pain that showed great improvement after less than two months of antibiotic treatment.

Keywords

Actinomycosis, Pulmonary, Chest wall mass

Introduction

Pulmonary actinomycosis is a rare infection in infants and children. Because of its non-specific clinical presentation, it can be confused with suppurative lung diseases or lung tumors. Actinomyces species are gram positive anaerobic bacilli, and of its many species, Actinomyces israelii is the most commonly reported. Most common anatomical sites of actinomyces infection are cervicofacial, thoracic and abdominal [1]. Here we report a case of a 12 year old Saudi boy with a chest wall mass that was biopsy proven to be caused by actinomyces. The patient presented electively to outpatient clinics and was admitted to our hospital for further workup. Aside from our case, a literature review of 35 cases of pediatric pulmonary actinomycosis was made.

Case Report

A 12 year old Saudi boy known case of partially controlled bronchial asthma, on Salbutamol, Fluticasone and Montelukast. The patient presented to outpatient clinic with one month history of a chest wall mass. Initially, it was painless, until one week prior to presentation, it started increasing in size and became erythematous, tender and warm, with the pain increasing with deep inspiration. There was no history of fever, cough, shortness of breath, night sweats, weight loss or any other swelling.

Examination revealed an afebrile, thin oriented child. His height was on 25th centile and weight below 5th centile. His oxygen saturation was 99% on room air; respiratory rate was 24/min, pulse of 104/min and blood pressure of 106/69 mm Hg. There was no spontaneous cough but he had poor oral hygiene. His chest examination showed a red, hot, tender and fluctuating right anterior non mobile chest wall mass measuring 4 × 10 cm (Figure 1) with no active discharge. On auscultation, there was decreased air entry on the right side with fine crepitations. The remainder of his examination was unremarkable.

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Figure 1: Chest examination

Investigations revealed hemoglobin level of 10.8 g/dL with a normal mean corpuscular volume and mean corpuscular hemoglobin. Leukocytes: 10.8 × 109/L with neutrophils: 7.08 × 109/L, lymphocytes: 2.63 × 109/L, platelets: 577 × 109/L, and C-Reactive Protein (CRP): 147 mg/L. Purified protein derivative skin test and gastric aspiration were both negative. Pulmonary function test was consistent with a restrictive pattern with vital capacity (VC) of 0.93 L (54% of predicted) and forced expiratory volume 1 (FEV1) of 0.91 L (61% of predicted) and FEV1/VC of 98%. A chest radiograph (Figure 2) was obtained and showed hyperinflation with right lung consolidation and pleural effusion. Computed Tomography (CT) scan with contrast was performed and showed (Figures 3 and 4) a right soft tissue mass in mid chest wall, measuring 10.3 × 3 cm involving lung parenchyma and pleural surface associated with periosteal reaction and destruction of the 5th, 6th and 7th rib.

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Figure 2: Chest radiograph

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Figure 3: Computed tomography (CT) scan with contrast shows lung parenchyma

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Figure 4: Computed tomography (CT) scan that shows periosteal reaction and destruction

Excisional biopsy and abscess drainage were performed with no complications and the patient was started on intravenous (IV) Augmentin. The pathology report revealed, after 4 days of performing the biopsy, the presence of acute and chronic inflammation and necrosis. The biopsy was negative for malignancy and tuberculosis, but positive for actinomyces species.

Ceftrixone IV was started on a dose of 90 mg/kg/day for a total of 30 days, to be received as an out on pass patient. During that time he was vitally stable and improving symptomatically. It was noticed that an itchy papular rash started to appear at the site of dressing and then involved the right upper limb, which resolved with anti-histamine treatment. The patient was started on oral Amoxicillin 500 mg three times per day for six weeks, with a follow up appointment after three weeks.

After three weeks of oral Amoxicillin, chest X-ray and CT (Figures 5 and 6) were done and showed significant decrease in size and opacity of the previously described actinomycosis of right lung and right chest wall, with a minimal residual pleural effusion and reaction around the involved ribs.

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Figure 5: Chest X-ray

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Figure 6: Chest CT with a minimal residual pleural effusion

Discussion

Our review (Table 1) consisted of 35 cases of pulmonary actinomycosis in patients aging 18 years and younger, gathered by using the Pubmed database. The first case was in 1958 and the last one in 2013. The average age was 9.5 years, ranging from 27 months to 16 years (17 male, 18 female). The most common presenting complaint was the same as the presenting complaint of our case, which was chest wall mass (49%). Then cough and fatigue (43%) followed, although our case did not have either one of these symptoms. followed by chest pain (37%) as the third most common manifestation. There were 3 cases that developed active discharge through draining sinus tracts, and only one case with positive history of chest trauma as a risk factor for infection [2]. Regarding the laboratory investigations, there were 10 cases that did not mention any lab work. However, the most common laboratory finding was leukocytosis, which occurred in 56% of cases, then elevated erythrocyte sedimentation rate (ESR) in 52%, followed by CRP elevation in 40%. On the other hand, we did not order ESR level in our case, and the WBC count was normal. For the imaging reports, there were nine cases that did not mention any imaging modality report. As for the remaining 26 cases, the most common radiological findings were consolidation with periostitis in 50%, followed by pleural effusion in 35%. Both findings were present in our case in addition to hyperinflation of the right lung. Regarding the microscopy report, sulphur granules were seen in 19 cases (58%) and branching filaments were seen in 16 (49%). There were 7 cases that required surgical intervention, mainly due to suspicion of malignancy. There were only three cases that did not use penicillin derivatives, and one case did not mention the specific antibiotic. However, as we did with our patient, the remaining 31 cases (91%) used penicillin derivatives.

Table 1. Pediatric pulmonary actinomycosis cases

  Authors Ref/Gender/Age Chest Wall Mass Cough Fatigue Chest Pain Weight Loss Pre-Treatment Imaging
1 Weese WC 2/M/10 - + + + + Not mentioned
2 Weese WC 2/M/5 - - - + - Not mentioned
3 Drake DP 3/F/3 - - - - - Not mentioned
4 Drake DP 3/F/5 - - - -   Not mentioned
5 Drake DP 3/M/7 + - - + - Clear
6 A.J. Thompson 4/M/15 + - + - + X-ray: consolidation, periostitis of ribs
7 A.J. Thompson 4/F/11 + - + + - X-ray: consolidation, periostitis of ribs
8 A.J. Thompson 4/F/7 + - - - - X-ray: collapse, consolidation with a mass
9 Lowe RN 5/M/14 - + + - - X-ray: pleural thickening, bilateral alveolar and interstitial infiltrates
10 Webb WR 6/F/7 - - + - - X-ray: density. CT: mass, periostitis. Bone radiography: rib destruction
11 Golden N 7/M/14 + + - - - X-ray: pleural thickening. CT: infiltration of lung parenchyma, periosteal reaction, soft tissue mass.
12 Hsieh MJ 8/F/16 + - - -   Not mentioned
13 Hsieh MJ 8/F/8 - + - - - Not mentioned
14 Hsieh MJ 8/M/8 - - - - - Not mentioned
15 Hsieh MJ 8/M/7 + - - + - Not mentioned
16 Hsieh MJ 8/M/8 + - - + - Not mentioned
17 Denton 3rd AE 9/M/11 + + + - + CT: infiltrate, pleural effusion, periostitis of ribs, chest wall mass
18 MASTERS B 10/F/9 - + + + + X-ray: bilateral collapse, consolidation of both lower lobes.
19 Dobson SR 11/F/10 + - - - - X-ray: consolidation, pleural effusion.
CT: abscess
20 Ray MS 12/M/12 - + + - + X-ray: consolidation, periostial new bone formation on ribs.
21 Hachitanda Y 13/M/11 + - + - - CT: mass involving chest wall and ribs
22 Wilson DC 14/M/10 + - + + + X-ray: chronic consolidation, pleural effusion, rib periostitis
23 Snape PS 15/F/10 + + - + + X-Ray: pneumonic infiltrate CT: probable inflammatory lesion extending through the chest wall
24 Wu CY 16/F/10 + + - - + X-ray: multiple nodules. CT: variable sized nodules, soft tissue mass.
25 Goussard P 17/M/5 - + - - + X-ray: consolidation
26 Kordes U 18/M/9 - + + - + X-ray: consolidation, pleural effusion.
27 Pinarli FG 19/F/9 - - + + - X-ray: consolidation, CT: soft tissue mass
28 Ganesan K 20/F/9 - + + + - X-ray: periosteal new bone formation. CT, MRI and Bone scan: suggest neuroblastoma or small cell carcinoma
29 Celebi S 21/F/11 - - - - - CT: solitary lesion, Scintigraphy: increased uptake in ribs
30 Bartlett AH 22/F/2 + - - - - X-ray: pleural effusion. MRI: chest wall mass, infiltration of pleura, diaphragm, liver and chest wall
31 Lee JK 23/F/12 - + - - + X-ray: pneumonic lesions. Sinogram: extension into subcutaneous tissues. CT: consolidation, pleural effusion.
32 Barikbin P 24/M/11 + - + - + X-ray, CT: mass infiltrating chest wall. MRI: infiltration of pericardium, intercostal and pectoral muscles, atelectasis.
33 Yeung VH 25/M/12 + + - - + X-ray consolidation, collapse. CT: chest wall tumor, pleural infiltration, rib erosion, lymph node metastases.
34 Lin CH 26/F/10 - - - + - X-ray: consolidation CT: soft tissue mass, atelectasis of adjacent lung
35 Briceño G 27/F/14 - + - + + CT: solid pulmonary mass with extension into the chest wall.

Pulmonary actinomycosis is not commonly encountered by pediatric physicians in Saudi Arabia. However, there are no epidemiological studies estimating the prevalence of this condition in our country. Most of the cases reported worldwide were caused by Actinomycosis israelii, which is a part of the normal flora of the mouth, and accordingly it is usually linked to poor oral hygiene. Pulmonary actinmycosis can range from asymptomatic disease to a fatal one. Because of its nonspecific findings in radiological imaging, it might simulate many other disorders including pneumonia, tuberculosis, cryptococcosis, histoplasmosis, or malignancy. As for the microscopy, sulfur granules with branching filaments are considered pathognomonic, although the specimen may not contain an area that has this typical appearance. Penicillin remains the drug of choice for actinomyces, unless contraindicated, then other alternatives might be used, such as cephalosporins and macrolides. Surgery is usually performed to rule out malignancy, but it might also be required to manage some complications, such as, empyema, sinus discharge or hemoptysis [1-10].

In conclusion, pulmonary actinomycosis is considered rare in the pediatric age group, but should always be in the differential diagnosis when dealing with a lung mass lesion involving the chest wall. Usually, histopathology remains the definitive diagnosis method, but other investigations and imaging modalities help narrow the differential diagnosis and monitor response to therapy [11-23]. Treatment of pulmonary actinomycosis consists of long term IV antibiotic followed by oral antibiotic therapy. Primarily, penicillin is considered the drug of choice, unless contraindicated. With proper antibiotic treatment the prognosis is good [24-27].

References