Review Paper - Biology & Medicine Case Reports (2018) Volume 2, Issue 1
Medicinal plants having anti-obesity potentiality available in Bangladesh: A review.Mahmudur Rahman AHM*, Md. Mahfuzur Rahman
Department of Pharmaceutical sciences, North South University, Dhaka, Bangladesh
- *Corresponding Author:
- Mahmudur Rahman AHM
Department of Pharmaceutical sciences North South University Dhaka Bangladesh
E-mail: [email protected]
Accepted date: December 13, 2017
Citation: Mahmudur Rahman AHM, Rahman MDM. Medicinal plants having anti-obesity potentiality available in Bangladesh: A review. Biol Med Case Rep. 2017;1(2):4-11.
Background: Obesity is a complex, severe and chronic disease that can have an unenthusiastic effect on many systems in human body. In traditional medication, many medicinal plants have been used to treat obesity. The aim of the present study is to present medicinal plants which are available in Bangladesh that proved their anti-obesity activities have been. Method: Bibliographic study was carried out by analyzing conventional text books and peer reviewed papers, consulting wide-reaching accepted scientific databases. In this review, the investigation terms were “obesity” in addition to (“herbal medicine” or “plant”, “medicinal plants” or “medicine traditional”) with no limiting search objects. Later it was cross checked whether the plants were available in the country or not from the Bangladeshi online medicinal plants databases. Findings: More than 100 plants have anti-obesity potentiality; however, only 23 species are available in Bangladesh. The plants are: Achyranthes aspera Linn, Acorus calamus Linn, Aegle marmelos Linn, Allium cepa Linn, Allium sativum Linn, Bombax ceiba L., Coccinia grandis (L.) Voigt, Cucumis melo L., Hibiscus sabdariffa L., Ipomoea batatas (L.) Lam, Morus alba L., Murraya koenigii (L.) Spreng, Nelumbo nucifera Gaertn, Phaseolus vulgaris L., Punica granatum L., Senna siamea (Lam.) H.S.Irwin & Barneby, Shorea robusta Gaertn, Solanum lycopersicum L., Syzygium aromaticum (L.) Merr. & L.M.Perry, Tamarindus indica L., Zingiber officinale Roscoe, Moringa oleifera and Citrus limon (L.). Conclusion: There are a lot of plants in Bangladesh which seem to be a safe treatment source for obesity control. Further researches are recommended to evaluate this potentiality for presenting effective and safe drugs for obesity in the market.
Obesity is fetching one of the most widespread health concerns amongst all populations and age groups all-inclusive, ensuing into a significant amplify in mortality as well as morbidity connected to coronary heart diseases, stroke, diabetes type 2, metabolic syndrome as well as cancers [1-4]. Choosing the best treatment for obesity depends on the accurate analysis. There are numerous complementary and integrative practices, including physical activity, dietary programs, surgical interventions, behavioral therapy, lifestyle modifications, medicinal therapies and the use of medicinal plants [5-10].
There are quite a few pharmacologic substances available as anti-obesity drugs, nevertheless they have risky side effects and therefore natural products have been used for treating obesity in many Asian countries and even in Bangladesh. Side effects with anti-obesity drug can differ depending upon the types of drugs we receive furthermore how the drug works. In the table, drug category and common side effects are mentioned. It is to be mentioned that weight loss medications are used beside a low calorie diet and a doctor-approved exercise plan intended for best results. In addition, it is to know that the majority people will get back some or all of the weight they lost when they discontinue using weight loss drugs if not efforts are made to keep their weight loss with diet and exercise. In the Table 1, generic name along with their category and common side effects are noted [11-15].
|Drug Name||Drug Category||Common Side Effects|
|Phentermine||Appetite suppressant||Increased blood pressure along with heart rate, insomnia, restlessness, dependence, nervousness, abuse or withdrawal may occur with long-term use|
|Orlistat||Lipase inhibitor||Flatulence, fecal urgency, soft stools, fecal incontinence|
|Lorcaserin||Appetite suppressant||Headache, dizziness, nausea, fatigue, dry mouth, constipation and also euphoria may occur with higher doses|
|Phendimetrazine||Appetite suppressant||Increased blood pressure and heart rate, dependence, insomnia, nervousness, restlessness|
|Bupropion and naltrexone||Antidepressant and an opioid antagonist||Nausea, vomiting, headache, fatigue, constipation, diarrhea, increased blood pressure, anxiety, tremor, hot flush, unusual taste dizziness, insomnia, dry mouth|
|Methamphetamine||Appetite suppressant||Increased blood pressure and heart rate, insomnia, nervousness, restlessness, dependence|
|Benzphetamine||Appetite suppressant||Increased blood pressure and heart rate, restlessness, insomnia, nervousness, dependence|
|Amfepramone||Appetite suppressant||Constipation, restlessness, dry mouth, insomnia, nervousness, restlessness, increased blood pressure and heart rate, dependence|
|Liraglutide||Regulates appetite and food intake.||Nausea/vomiting, diarrhea, constipation, headache, heartburn, fatigue, dizziness, low blood sugar in type 2 diabetes, increased lipase stomach pain, gas, dry mouth|
Table 1: Common side effects of anti-obesity drugs.
At the present time, while of high cost and potentially risky side effects, the need for natural products against obesity is under investigation which may be an alternative strategy for developing effective, safe antiobesity drugs and within economical risk [16-18]. It is also known that natural anti-obesity preparations can induce weight loss through several mechanisms with less risk of side effects [19-21].
To date, many reviews on anti-obesity agents have been consummate but focusing only Bangladeshi medical plants with anti-obesity activities still not found. Therefore, the aim of the present review was to collect or update data on potential antiobesity herbal plants available in Bangladesh and assess the scientific data including active components and mechanisms of action against obesity in human.
Conventional text books and databases such as Web of Science, Scopus, and PubMed were searched for scientific articles published till 2017, using the following descriptors: “herbal medicine” or “plant”, “medicinal plant” or “medicine traditional”, without restriction on the language of the articles and without limiting the search items.
Inclusion and exclusion criteria
Both original works and reviews on medicinal plants were considered, including those that cited the plant species referenced for obesity treatment, with botanical identification correctly described according to the Ethnobotanical Database of Bangladesh (EDB) (http://www.ethnobotanybd.com/) and Medicinal Plants of Bangladesh (http://www.mpbd. info/). Ethnopharmacological articles that presented possible methodological bias in terms of sample quality and authenticity of the species described in the study were not considered.
To analyze and manufacture the objects, an exploratory reading of the bibliographic materials were conducted, assessing the title and abstract of the work. After that, the articles that appeared in the results of all were checked. After completing the exploratory analysis, a selective reading of the articles that included plant species with botanical records were done and were checked in as information contained in the consulted periodicals were performed, thus enabling the collection of the data from the bibliographic review. Information on anti-obesity action was obtained directly from the selected articles [22-50].
Results and Discussion
There were more than 100 medicinal plants available worldwide introduced as anti-obesity plants but in Bangladesh, there were only 23 medicinal plants available for this purpose. For easy understanding, information about these Bangladeshi plants is provided in tables. In the Table 2, there is the list of these plants with local names, common names and their family names. In Table 3, the using parts and mechanism actions of the plants are included. Finally, in Table 4, their short description and chemical composition are provided [51-54].
|Serial no.||Scientific name||Common Name||Local name||Family|
|1||Achyranthes aspera Linn||Prickly Chaff-flower||Apang||
|2||Acorus calamus Linn||Calamus||Bach||Acoraceae|
|3||Aegle marmelos Linn||Wood Apple||Bel||
|4||Allium cepa Linn||Onion||Piyaj||Liliaceae|
|5||Allium sativum Linn||Garlic||Rasun||Liliaceae|
|6||Bombax ceiba L.||Silk Cotton Tree||Shimul-tula||Bombacaceae|
|7||Coccinia grandis (L.)
|8||Cucumis melo L.||Musk Melon||Bangi||Cucurbitaceae|
|9||Hibiscus sabdariffa L.||Indian Sorrel, Jamaica Sorrel||Lalmesta||Malvaceae|
|10||Ipomoea batatas (L.)
|11||Morus alba L.||Malberry, white mulberry||Tut||Moraceae|
|12||Murraya koenigii (L.)
|14||Phaseolus vulgaris L.||Kidney bean||Bakola||Fabaceae|
|15||Punica granatum L||Pomegrante||Dalim||Punicaceae|
|16||Senna siamea (Lam.)
H.S.Irwin & Barneby
|17||Shorea robusta Gaertn||Sal tree||Sal, Gajari||Dipterocarpaceae|
(L.) Merr. & L.M.Perry
|20||Tamarindus indica L.||Tamarind tree||Tetul||Fabaceae|
|21||Zingiber officinale Roscoe||Ginger||Ada||Zingiberaceae|
|22||Moringa oleifera||Drumstick Tree||Sajna||Moringaceae|
|23||Citrus limon (L.)||Lime||Lebu||Rutaceae|
Table 2: List of the medicinal plants with anti-obesity potentiality in Bangladesh with common names, local names and family. names.
|Serial no.||Scientific name||Used part(s)||Mechanism||Reference|
|1||Achyranthes aspera Linn||Seed||The plant reduces total triglycerides, cholesterol, and LDL-cholesterol, and also increases HDL cholesterol level.||23|
|2||Acorus calamus Linn||Rhizome, roots
|Ethyl acetate extarct derived from A. calamus suppresses α-glucosidase
|3||Aegle marmelos Linn||Leaves||The active chemical constituents of A. marmelos are responsible for the lowering of adipocyte accumulation.||25, 26|
|4||Allium cepa Linn||Peel||The mRNA levels of activating protein (AP2) is downregulated by A.cepa and Fatty acid binding protein 4(FABP4) and carnitine palmitoyl transferase-1 α (CPT-1α) are up-regulated by this.||27, 28|
|5||Allium sativum Linn||Stem, Bulb and
|It suppresses glutathione depletion and lipid peroxidation in hepatic tissue. It also increases antioxidant enzymes.
Oil derived from A. sativum down regulates sterol regulatory element binding protein1c,fatty acid synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and acetylcoA carboxylase.
|6||Bombax ceiba L.||Stem bark||The extract and active constituent gemfibrozil alters the effects of HFD treatment on serum parameters. This occurs as they activate AMPK which causes thermogenesis and FAS inhibition.As a result, acetyl-coA carboxylase is inactivated.||31|
|7||Coccinia grandis (L.)
|Fruit||C. grandis decreases body weight, organ and fat pads weight,food intake, and CHO ,serum GLU, TRG, LDL and VLDL cholesterol levels and increases the formation of HDL.||32|
|8||Cucumis melo L.||Fruit peel||C. melo decreases body weight, total cholesterol,LDL cholesterol level, triglyceride, atherogenic
index and increases HDL cholesterol levels.
|9||Hibiscus sabdariffa L.||Leaf||H. sabdariffa Promotes LXRα/ABCA1 pathway, helps to remove cholesterol from macrophages, and delays atherosclerosis.
Also, the extract of H. sabdariffa reduces fat in the liver, downregulates SREBP-1c and PPAR-γ, inhibits the increase of IL-1, TNF-α mRNA and lipoperoxidation.
|10||Ipomoea batatas (L.)
|Fruit||I.batatas opposes the expression of SREBP-l, Acyltransferase, Glycerol-3-Phosphate, Acyl-CoA Synthase, HMG-CoA Reductase and Fatty Acid Synthase in liver tissue in mice.||36|
|11||Morus alba L.||Fruit, leaves||It reduces fatty acid synthase, hepatic lipids and 3-hydroxy-3 methylglutarylcoenzyme
A (HMG-CoA) reductase and increases carnitine palmitoyltransferase-1 and hepatic peroxisome PPAR-α.
|12||Murraya koenigii (L.)
|Leaves||It decreases weight gain, triglyceride and cholesterol levels in mice.||38|
|The extracts of N. nucifera effectively inhibits preadipocyte differentiation. The flavonoids inhibits adipocyte differentiation and pancreatic lipase activity and decreases activity of PPARγ, GLUT4, and leptin. The methanol extract blocks lipase activity and decreases acetyl-CoA carboxylase, fatty acid synthase, and HMGCoA reductase and elevates the phosphorylation of AMP-activated protein kinase in the liver.||39,
|14||Phaseolus vulgaris L.||Bean||It decreases food intake and weight gain in animal model and ultimately it controls glucose level in blood.||41|
|15||Punica granatum L||Leaves, seed||It contains punicic acid which attaches, activates and upregulates PPAR α and its responsive genes (Carnitine palmitoyltransferase1,Stearoyl-CoA desaturase-1, and acylcoenzyme A dehydrogenase) and PPAR γ and its responsive genes (Fatty Acid Binding Protein 4 and CD36) in intra-abdominal white adipose tissue.
Punicic acid also inhibits expression of the inflammatory cytokine TNF-α and NF-κB activation.
|16||Senna siamea (Lam.)
H.S.Irwin & Barneby
|Roots||Active constituents of S. siamea including physcion, chrysophanol, cassiamin A, emodin, friedelin and cycloart-25-en-3,24-diol shows pancreatic lipase inhibitory activity.||43|
|17||Shorea robusta Gaertn||Leaves||S. robusta reduces serum glucose, cholesterol, LDL cholesterol , VLDL cholesterol, atherogenic index, triglyceride, SGOT and SGPT.||44|
|Fruit||S. lycopericum increases acetyl-CoA carboxylase phosphorylation and AMP-activated protein kinase in liver and decreases peroxisome PPAR- γ, HMG-CoA reductase, CCAAT/enhancer binding protein alpha and perilipin in the adipose tissue.||45|
(L.) Merr. & L.M.Perry
|Flower buds||The extract of S. aromaticum inhibits the activity of lipid metabolism related proteins including CD36, FAS, PPARγ, and SREBP-1 in the liver.||46|
|20||Tamarindus indica L.||Fruit pulp, pulp,
|It decreases total cholesterol, LDL-C, and triglyceride and elevates the level of HDL.||47|
|21||Zingiber officinale Roscoe||Rhizome||Z. officinale blocks the hydrolysis of dietary fat and ultimately suppresses the intestinal absorption.||48,
|22||Moringa oleifera||Leaves||M. oleifera reduces total lipid content from body.Thus reduces body weight.||50|
|23||Citrus limon (L.)||peel||It upregulates the peroxisomal β-oxidation through increasing mRNA level of acyl-CoA oxidase in the liver and white adipose tissues, which is mediated via up-regulation of the mRNA levels of PPARα.||51|
Table 3: Anti-obesity potential Bangladeshi medicinal plants with their used part (s) and mechanism.
|Serial no.||Scientific name||Short
|1||Achyranthes aspera Linn||It is an erect, diffuse herb, fine-pubescent. Leaves are simple and opposite. Flowers are greenish-white in terminal spikes. Seeds are shining. Fruits are deflexed.||Leaves, stems and roots of this plant contain alkaloids, saponins and sterol. Root contains ecdysone, ecdysterone. Seeds contain saponin A&B. Fruit contains two oleanolic acid based saponins. The plant also contains an alkaloid achyranthine, arginine, histidine, lysine, cystine, amino acids, threonine, lucine, isolucine, methionine, phenylalanine, tryptophan and carbohydrate, large amount of potash, valine, α-rhamnopyranosyl, β-D galactopyranosyl, galactose, xylose, β-D gluuronopyranosyl, rhamnose and glucose, hormones, ecdysterone and inokosterone|
|2||Acorus calamus Linn||Rhizome of the plant is pinkish and leaves are asymmetric. Flowers are in straight or slightly curved spadix and fruits are berries.||Rhizome contains an essential oil with β-asarone as major constituent and also ecgenol methyl ether, sesquiterpene alcohols, calamenenol, isocalamendiol, and palmitic acid. Aerial parts contain the choline , alkaloid and acorin glycosides and fresh leaves contain calcium andoxalic acid.|
|3||Aegle marmelos Linn||It is basically a medium sized thorny tree. Leaves are sub-crenulate, acute and glabrous. Flowers are white in axillary panicles. Fruit is a large globose berry. Seeds are embedded in fleshy pilp.||Fruit pulp contains proteins, carbohydrates, minerals and vitamins, essential oil, marmesin, scopoletin, tannins, alcohols, ester, terpene. Fruit contains furanocoumarin, marmelide, psoralen, tamic acid, agelinol. Leaves also contain marmesin, rutin, polyphenolic compounds, sitosterols and essential oil containing of α & β-phellandrene alkaloids, marmelosins and agelenine. Root contains tembamide, umbelliferone, marmesin, marmin, skimmianine xanthotoxin, 6,7-di-Ome-coumarin and scopoletin. Bark contains aurapten, marmin, and umbelliferone, β-sitoterol, umbelliferone, lupeol, coumarin and alkaloids, skimmianine, marmesin.|
|4||Allium cepa Linn||It is an annual herb. Stem underground and modified in to small disc generally known as bulb. Leaves are radical long cylindrical and flowers are arranged in a terminal umbel. Fruit is a loculocidal capsule and membernous.||An essential oil as a principal constituent containing various sulphur compounds such as mono-, di-, tri-, and tetra-sulphides, thiophene and thiols derivatives. It also contains carbohydrates, proteins, kaempferol, vitamin B and C, a saponin, β-amyrin, amino acids, polyphenols, quercetin, sterols, phenolic acids and minerals. Diosgenin has been separated from flowers and bulb.|
|5||Allium sativum Linn||It is like bulbs ovoid, compressed of many bulblets. Leaves are flat, and keeled beneath. Stem is solid. Inflorescence is composed of not less than 3 bulbils.||An essential oil which is chief chemical constituent of Garlic contains diallyl disulphide, allyl propyl disulphide, dimethyl disulphide and polysulphides. Vitamins A, B, C and α-tocopherol (vitamin E) have also been isolated from garlic. Garlic also contains prostaglandins A2 and F1.|
|6||Bombax ceiba L.||It is a large sized tree. Leaves are digitately compound and elliptic.||Stem and root bark contains phenolic substances, a lactone, lupeol, β-sitosterol, naphthoquinone compound and 4 sesquiterpenes. Root yields β- sitosterol, triacontanol and new glycosides. Flower petals yield vital oil.|
|7||Coccinia grandis (L.)
|It is a climbing herbaceous annual. Stems and coiled are tendrils. The leaves are alternate and stipules are absent. The flowers are actinomorphic and almost always unisexual. The fruit is a kind of berry called a pepo.||Aerial parts hold protein, fat, mineral, carbohydrates, vitamin C, sterols, β-sitosterol, phenolic compounds, triterpenoids, β-amyrin, β-amyrine acetate and lupeol, bitter glycoside constituents. Fruits contain β-amyrin, lupeol and a bitter glycoside having cucurbitacin B. β-Sitosterol, lycopene, cryptoxanthin, taraxerone, β-carotene, apo-6'-lycopenal taraxerol and ethylcholesterol gluciside. Roots contain lupeol acetate, β-amyrin acetate and β-sitosterol.|
|8||Cucumis melo L.||It is a robust, annual climbing herb. Stems are hirsute, prostrate, angular. Tendrils filiform, puberolous. Leaves are sub orbicular and lobe obtuse. Fruits are changeable in size and shape.||Fruit tail contains cucurbitin, cucurbitacin B and E and sterols and seeds contain an edible fixed oil.|
|9||Hibiscus sabdariffa L.||It is an erect shrubby annual with red stem and branches. Leaves are cuneate at the base and lobes lanceolate. Flowers are large.||The leaves, fruits and stems contain d-malic acid and leaves contain sitosterol- β-D-galactoside. Extract of flowers contain glycosides, reducing sugars, acids, an alkaloid and resins.|
|10|| Ipomoea batatas (L.)
|It is a prostrate herb with trailing stem along with tuberous roots. Leaves are ovate-cordate and acute angular or more or less lobed.||Leaves are a superior source of vitamins B and C. Sweet potato in addition contains enzymes, scopoletin and some fungicidal and bactericidal substances.|
|11||Morus alba L.||It is a small tree or shrubs with milky juice. Leaves are simple and alternated. Flowers are dioecious or monoecious. The fruit is not a berry except a collective fruit.||Leaves have flavonoids, salts of citric and malic acids anthocyanins and artocapin. Fruits are rich in vitamins A, B1, B2 and C as well as minerals. Stems and bark contain pectin along with sugars.|
|12||Murraya koenigii (L.)
|It is a strong smelling and shrub tree. Leaves are pinnately compound.
Flowers are small and fruits are ovoid or subglobose.
|Leaves have an essential oil, tannins, glucoside, koenigin, koenigicine, koenidine, koenimbine, resin, cyclomahanimbine, koemine, koenigine, mahanine, mahanimbidine and scopolin. Fruits and seeds have the carbazole alkaloids, koenimbine, koenigicine, mahanine, mahanimbine, murrayazolidine, girinimbine, iso-mahanine and murrayanol. Stem-bark has murrayanine, murrayacine, girinimbin, girinimbine, and a carbazole carboxylic acid - mukoeic acid, curryangine and curryanine. Flowers have a large number of mono- and sesquiterpenoids. Plant too contains mukonine in addition to mukonidine.|
|It is an aquatic plant. Leaves are peltate and broad. Fruits are torus and spongy. Seeds looked similar to capsules.||Leaves, pedicels and embryo have alkaloids, nornuciferine, pronuciferine, roemerine, anonaine, 5-methoxy-6-hydroxyaporphine and meratin hyperoside, quercetin, nelumbine and nupharine, nuciferine, isoquercetin, a quercetin glucoside,
nelumboside, luteolin and glucoluteolin. Rhizomes and seeds have tannin, fat, resins, glucose and the alkaloid nelumbine.
|14||Phaseolus vulgaris L.||It is highly polymorphic species and annual herb. Leaves are alternate and green or purple. Flowers are zygomorphic and variegated. Fruits are green and yellow.||The contents of analyzed compounds are protein, lipids, carbohydrates and starch.|
|15||Punica granatum L||It is a small multi-stemmed shrub or else small tree. Stems are woody and spiny. Leaves are simple and oppositely placed. Flowers are regular and solitary and fruits round berry globose with persistent callipe.||Bark, fruit rind and fruit juice contain alkaloids pelletierine isopelletierine, pseudopelletierine and methyl-isopellerierine, sucrose, isoquercetin, β-sitosterol, friedelin, estrone, pectin, sorbitol, mannitol, glucose, fructose, triterpenoids, ellagitannins (about 25%), citric acid (about 9%), phosphorus, iron, oxalic acid, calcium, sodium and potassium. Leaves have betulic in addition to ursolic acids and β-sitosterol. Flowers have sitosterol, acetic, ursolic, maslinic, asiatic, ellagic and gallic acids.|
|16||Senna siamea (Lam.)
H.S.Irwin & Barneby
|It is a medium to large tree. Leaflets are elliptic-oblong. Flowers are yellow.||Leaves contain
protein, crude fibre, moisture content, ash content, carbohydrate, iron, magnesium, manganese, potassium, calcium, sodium, copper, phosphorus.
|17||Shorea robusta Gaertn||It is a medium-sized to large deciduous tree. Barks are dark-grey or brown.Young leaves are reddish and mature leaves are yellowish or dark green. Fruits are samara and ovoid.||Barks have tannic principles, a gummy resin, polyphenol, hopeaphenol, lignin and starch. Seeds also have phenolic acid, ellagic, shorbic acid, corilagin, chebulinic and gallic acids.|
|It is an undershrub. Leaves are imparipinnate. Flowers are yellow. Berries are fleshy and red when ripe.||
Leaves contain glycol-alkaloides, tomatine, traces of solanine, amino acids and amides and tomatidine. Seeds have neotigogenin, quercetin, kaempferol, 24-methylenecycloartanol, lupeol, lanost-8-en-3β-ol, lanosterol, 24-methylenelanost-8-en-3β-ol, cycloartanol, β-amyrin, α- & β-globulins and daturadiol. Fruits have all the important amino acids except tryptophan and organic acids, mainly citric, oxalic and malic acids. Stem contains leucine, phenylalanine, glutamic acid, tyrosine, isoleucine, valine and γ-aminobutyric acid.
(L.) Merr. & L.M.Perry
|It is a small tree. Leaves are narrowly elliptic to obovate. Flowers are fragrant. Fruit are oblong and crowned.||Eugenol is the main essential oil extracted from cloves and other important essential oil constituents of clove oil comprise acetyl eugenol, tannins such as bicornin, gallotannic acid, beta-caryophyllene and vanillin, crategolic acid, methyl salicylate, the flavonoids eugenin, kaempferol, rhamnetin, and eugenitin, triterpenoids, stigmasterol, and campesterol and several sesquiterpenes.|
|20||Tamarindus indica L.||It is a tree and leaves pinnately compound. Flowers are racemes yellow. Fruits are pods and compressed. Seeds are orbicular and blackish brown.||Fruit pulp has large quantities (16-18%) of tartaric, potassium tartrate, citric, malic and acetic acids, invert sugar, gum and pectin. Leaves have glycosides and bark contains tannins as well as resin.|
|21||Zingiber officinale Roscoe||It is a rhizomatous herb. Leaves are oblong-lenceate and acuminate. Flowers are pale yellow within spikes.||Rhizome has essential oil, starch, protein, acrid oleoresin, lipids and sugars. Resin contains gingeodiols, gingerol, shogaols, and gingediacetates. Rhizome yields essential oil which contains 25 different monoterpene and sesquiterpene compounds.|
|22||Moringa oleifera||It is a large tree. Leaves are pinnate. Flowers are white. Fruits are elongated capsule.||Barks of the trunk yield a tragacanth-like gum which has bassorin galactose, dextrose, glucuronic acid, , β-sitosterol, enzyme and sugars, arabinose and rhamnose. Root bark contains alkaloids. Seeds have fixed oil along with fatty acids. Flowers and fruits also contain sucrose and glucose. Leaves also have glycine, threonine, alanine, aspartic acid, glutamic acid, valine, leucine, arginine, phenylalanine, tryptophan, isoleucine, histidine, lysine, cysteine and methionine. Each fraction of the plant contains substantial quantity of K, Mg, Zn and Ca.|
|23||Citrus limon (L.)||The lemon tree reaches 10 to 20 ft (3-6 m) in height in addition to usually has spiky thorns on the twigs. The fruits are oval with a nipple-like protuberance at the peak.||The fruit has protein, fat, ash, fiber, sodium, potassium, calcium, copper, iron, magnesium, zinc and phosphorus.|
Table 4: Anti-obesity potential of Bangladeshi medicinal plants with their short description and chemical compositions.
Dosage of anti-obesity medicinal plants
There were various researches held on anti-obesity medicinal plants and still going on. It is to be mentioned that there is not any fixed dose were found for obesity control. In different experiments, the dose ranges is different.
It is very well known that natural alternatives may provide increased health expectancy in obesity control. In Bangladesh, several plants possess anti-obesity potential but have been poorly studied by the local researchers, while others are not even promoted. More anti-obesity data is needed about those plants, but in order to accomplish this, more researches in this area with well-designed clinical trials focused on both safety and efficacy with these plants materials is required.
- Eckel RH, York DA, Rössner S, et al. American Heart Association: Prevention Conference VII obesity, A Worldwide epidemic related to heart disease and stroke: Executive summary. Circulation. 2004;110:2968-75.
- Field AE, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med. 2001;161:1581-86.
- Panel NO. Expert panel on the identification, evaluation, and treatment of overweight in adults: Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr. 1998; 68:899-17.
- Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia. 2000;71:73-82.
- Baren JM, Mace SE, Hendry PL. Children's mental health emergencies-part 3: special situations: child maltreatment, violence, and response to disasters. Pediatr Emerg Care. 2008;24:569-77.
- Picchio M, Briganti A, Fanti S, et al. The role of choline positron emission tomography/computed tomography in the management of patients with prostate-specific antigen progression after radical treatment of prostate cancer. Eur Urol. 2011;59:51-60.
- Apovian CM, Aronne LJ, Bessesen DH, et al. Pharmacological management of obesity: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2015;100:342-62.
- Greenway F, Liu Z, Martin C, et al. Safety and efficacy of NT, an herbal supplement, in treating human obesity. Int J Obesity. 2006;30:1737-41.
- S. Haaz, K. Fontaine, G. Cutter et al. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity reviews. 2006;7:79-88.
- Hansen JC, Gilman AP, Odland J, et al. Is thermogenesis a significant causal factor in preventing the “globesity” epidemic? Medical hypotheses. 2010;75:250-56.
- Heber D. Herbal preparations for obesity: Are they useful? Primary care. 2003;30:441-63.
- Hsu CL, Yen GC. Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. J Agr Food Chem. 2007;55:1730-36.
- Kaur H, Hyder M, Poston W. Childhood overweight: An expanding problem. Treat Endocrinol. 2003; 2:375-88.
- Hall D, Cole T. What use is the BMI? Arch Dis Child. 2006; 91:283-86.
- Kaufman J, Durazo-Arvizu R, Rotimi C, et al. Obesity and hypertension prevalence in populations of African origin. The investigators of the international collaborative study on hypertension in blacks. Epidemiol. 1996;7:398-405.
- Rubenstein H. Obesity: A modern epidemic. Trans Am Clin Climatol Assoc. 2011;116:103-13.
- Greenway F, Smith S. The future of obesity research. 2000;16:976-82.
- Barakat H, Lendon V, Marks R, et al. Influence of morbid obesity and non-insulin dependent diabetes mellitus on HDL composition and subpopulation distribution. 1992;41:37-41.
- Calle E, Rodriguez C, Walker T, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. 2003;348:1625-38.
- Bergman RN, Stefanovski D, Buchanan TA, et al. A better index of body adiposity. Obesity. 2011;19:1083-89.
- khan Afridi A, Khan A. Prevalence and etiology of obesity-An overview. P J Nutr. 2004;3:14-25.
- Rani N, Sharma SK, Vasudeva N. Assessment of anti-obesity potential of Achyranthes aspera Linn. seed. Evidence-Based Complementary and Alternative Medicine. 2012; 27.
- Mythili Avadhani MN. The sweetness and bitterness of sweet flag (Acorus calamus L.) – A Review. Res J Pharm Biol Chem Sci. 2013;4:598-610.
- Karmase A, Birari R, Bhutani KK. Evaluation of anti-obesity effect of Aegle marmelos leaves. Phytomedicine. 2013;20:805-12.
- Karmase A, Jagtap S, Bhutani KK. Anti adipogenic activity of Aegle marmelos Correa. Phytomedicine. 2013;20:1267-71.
- Kim OY, Lee SM, Do H, et al. Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats. Phytother Res. 2012;26:432-37.
- Moon J, Do HJ, Kim OY, et al. Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats. Food Chem Toxicol. 2013;58:347-54.
- Kim I, Kim HR, Kim JH, et al. Beneficial effects of Allium sativum L. stem extract on lipid metabolism and antioxidant status in obese mice fed a high-fat diet. J Sci Food Agric. 2013;93:2749-57.
- Lai YS. Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. J Agric Food Chem. 2014;62:5897-5906.
- Gupta P, Goyal R, Chauhan Y, et al. Possible modulation of FAS and PTP-1B signaling in ameliorative potential of Bombax ceiba against high fat diet induced obesity. BMC Complement Altern Med. 2013;13:281.
- Ahmed SM, Manoj J. Antiobesity activity of Coccinia indica in female rats fed with cafeteria and atherogenic diets. Der Pharmacia Lettre. 2012;4:1480-85.
- Bidkar JS, Ghanwat DD, Bhujbal MD, et al. Anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats. J Comp Int Med. 2012;9.
- Patel S. Hibiscus sabdariffa: An ideal yet under-exploited candidate for nutraceutical applications. Biomedicine & Preventive Nutrition. 2014;4:23-27.
- Villalpando-Arteaga EV, Mendieta-Condado E, Esquivel-Solís H, et al. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-Î³ and SREBP-1c in diet-induced obese mice. Food Funct. 2013;4:618-26.
- Ju JH, Yoon HS, Park HJ, et al. Anti-obesity and antioxidative effects of purple sweet potato extract in 3T3-L1 adipocytes in vitro. J Med Food. 2011;14:1097-06.
- Yang Y, Yang X, Xu B, et al. Chemical constituents of Morus alba L. and their inhibitory effect on 3T3-L1 preadipocyte proliferation and differentiation. Fitoterapia. 2014; 98:222-27.
- Birari R, Javia V, Bhutani KK. Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia. 2010;81:1129-33.
- Ahn JH, Kim ES, Lee C, et al. Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorg Med Chem Lett. 2013;23:3604-08.
- Du H. Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci. 2010;17:42.
- Carai MA, Fantini N, Loi B, et al. Multiple cycles of repeated treatments with a Phaseolus vulgaris dry extract reduce food intake and body weight in obese rats. Br J Nutr. 2011;106:762-68.
- Adnyana IK. Anti-obesity effect of the pomegranate leaves ethanol extract (Punica granatum L.) in high-fat diet induced mice. Int J Pharm Biol Sci. 2014;6:626-31.
- Kumar D, Karmase A, Jagtap S, et al. Pancreatic lipase inhibitory activity of cassiamin A, a bianthraquinone from Cassia siamea. Nat Prod Commun. 2013;8:195-98.
- Supriya KSK, Vrushabendra Swamy BM, Archana Swamy P, et al. Anti-obesity activity of Shorea robusta G. leaves extract on monosodium glutamate induced obesity in Albino rats. Res J Pharm Biol Chem Sci. 2015;6.
- Choi KM, Lee YS, Shin DM, et al. Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice. J Nutr Biochem. 2013; 24:335-42.
- Jung CH, Ahn J, Jeon TI, et al. Syzygium aromaticum ethanol extract reduces high-fat diet-induced obesity in mice through downregulation of adipogenic and lipogenic gene expression. Exp Ther Med. 2013;4:409-14.
- Bao L, Deng A, Li Z, et al. Chemical constituents of rhizomes of Zingiber officinale. China journal of Chinese materia medica. 2010;35:598-601.
- Shidfar F, Rajab A, Rahideh T, et al. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. 2015;12:165-70.
- Chumark P, Khunawat P, Sanvarinda Y, et al. The in vitro and ex vivo antioxidant properties, hypolipidemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. 2008;116:439-46.
- Fukuchi Y, Hiramitsu M, Okada M, et al. Lemon polyphenols suppress diet-induced obesity by up-regulation of mRNA levels of the enzymes involved in β-oxidation in mouse white adipose tissue. J Clin Biochem Nutr. 2008;43:201.
- Asolkar LV, Kakkar KK, Chakre OJ, et al. Second supplement to glossary of indian medicinal plants with active principles. Part-1 (A-K), CSIR, New Delhi, India. 1992.
- Rastogi, Ram P, Mehrotra BN. Compendium of Indian Medicinal Plants. Vol. 1, Central Drug Research Institute, Lucknow and Publicatios & Information Directorate, New Delhi, India, 1991.
- Ghani, A. 2002. Medicinal Plants of Bangladesh with chemical constituents and uses. 2nd edition, Asiatic Society of Bangladesh, 5 old Secretariate road, Nimtali, Dhaka, Bangladesh.
- Ghani A. Medicinal plants of Bangladesh: chemical constituents and uses. Asiatic society of Bangladesh; 1998.
- Gain P. The Chittagong hill tracts: life and nature at risk. Society for Environment and Human Development. Dhaka: University Press Limited. 2000.