Biomedical Research

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Research Article - Biomedical Research (2017) Volume 28, Issue 5

Two novel Cd (II) and Cu (II) complexes based on 3, 5-bi (4-carboxyphenoxy)-benzoic acid: anti-inflammatory activity in sympathetic ophthalmia

The reactions of a semirigid tripodal carboxylic ligand 3, 5-bi (4-Carboxyphenoxy)-Benzoic Acid (H3BCPBA) with Cd (NO3)2 and CuCl2 • 2H2O afford two novel coordination polymers, ((Cd3(BCPBA)2) (DMA))n (1) and [Cu2(HBCPBA)2(DMA)3]n (2) (DMA=N, N-dimethylacetamide), in which 1 shows a three-dimensional (3D) structure with a 5, 6, 6-connected net structure and 2 features a non-interpenetrating 3D networks with 1D small-size channels running along the a axis. In addition, anti-inflammatory properties of the synthesized compounds were evaluated in vivo utilizing a standard acute carrageenan-induced paw oedema method in rats.

Author(s): Li Sun, Li-Yan Sha, Jing Jiang

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