Glioma is the most common and aggressive primary adult brain tumor. The median survival time of the glioma patients is less than 15 months under conventional treatments. The etiology of the glioma is still unknown. The emerging evidence suggested that many factors contributed to human glioma formation, metastasis, relapse, and resistant to radiation, and chemotherapy/therapies resistance. Recent reports showed that the long non-coding RNAs (lncRNAs) had multifunctional roles in regulating human glioma tumorogenesis processes through both transcriptional and post-transcriptional regulation of gene expression. In this review, the related lncRNAs which have been reported were summarized, the functions of the lncRNAs which acted as oncogenes or tumor suppressor genes during human glioma development was discussed, and the current mechanisms of lncRNAs was elaborated in a variety of biological properties of human glioma.