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The effect of Lacidipine on Ischemia-Reperfusion Induced oxidative damage in ovaries of female rats

In this study, we investigated the effects of lacidipine on XO, MDA, MPO, and GSH levels in ovarian tissues of rats, which are subjected to ischemia and post-ischemic reperfusion. In ovarian ischemia (OI), ovarian ischemia-reperfusion (OIR), 2 mg/kg lacidipine + ovarian ischemia (LOI-2), 4 mg/kg lacidipine + ovarian ischemia (LOI-4), 2 mg/kg lacidipine +ovarian ischemia-reperfusion (LOIR-2), 4 mg/kg lacidipine + ovarian ischemia-reperfusion (LOIR-4) and sham-operated healthy control group (HCG); XO 23.8±0.94, 13.6±0.76, 8±0.57, 5.8± 0.60, 4.5± 0.42, 3.6±0.55, 2.8± 0.30 u/g, respectively, whereas MDA, 4.8±0.47, 13.33± 0.66, 3.5±0.35, 3.4±0.42, 6.0±0.57, 5.3±0.61,2.8± 0.22 μmol/g protein, respectively . MPO, 6.1± 0.60, 14.1± 0.94, 6.3± 0.66, 6.0± 0.73, 8.8± 0.60, 7.5± 0.76, 6±1.06 u/g protein, respectively, while GSH 8.0±0.73, 3.1±0.47, 8.6±0.95, 8.9±0.91, 7.1±0.60, 7.5±0.76 ,9.1±0.47 nmol/g protein, respectively. The present study, conducted on the basis of the mechanism of formation of IR injury, demonstrated that lacidipine prevents ischemia-reperfusion injury in the ovarian tissues.

Author(s): Serkan KUMBASAR, O.Erkan YAPCA, Habib BILEN, Bahadir SULEYMAN, F. Betul OZGERIS, Bunyamin BOREKCI, Halis SULEYMAN