Biomedical Research

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The clinical research on pathology classification and gene expression of breast cancer

To study the expression of breast cancer susceptibility gene 1 (BRCA1) and Ki-67 in young patients with breast cancer and the clinical research significance, and discuss the pathology classification of breast cancer. And a total of 218 patients are investigated as experiment for clinical study. Patients with early clinical stages I and II breast cancer were recruited across the West Midlands, and were randomized to immediate postoperative radiotherapy or follow-up only, as results of the expression of BRCA1 in breast cancer tissue and clinical pathological indicators of positive are 6, 28, 5, while the expression of negative are 3, 34 and 21, respectively. And it was found that alcohol consumption did not increase the risk of breast cancer among women with a BRCA1 or BRCA2 mutation. Increasing consumption of wine was associated with a modest reduction in the risk of breast cancer among women with a BRCA1 mutation.

Author(s): Jiali Liu, Rongwei Ji, Jiali Liu