Background: Previous epidemiologic studies have revealed that cumulative body mass index (BMI) is allied with higher total cholesterol and low-density lipoprotein cholesterol (LDL). However, these scholarships were limited by the underrepresentation of obese subjects according to Shamai. Objective: To evaluate the association between body mass index (BMI) and total cholesterol among some Algerian women's. Methods: A case-control study was performed involving some worker’s women and spinster in OPAPS laboratory for the academic years (2015-2016). All participants in this study accepted to venous blood withdrawal under fasting conditions and anthropometric measurement (body weight, body height and body mass index). The datum was performed by SPSS 22 using Levene’s statistic, T-test independently and correlation of Pearson. Result: the samples included 36 females 18 spinsters and 18 married, their average age 22.75 ± 2.56 years. The homogeneity of the two groups was based on administrative workers with the same education and the social status. Founded on the statistical applied, we confirm that cholesterol level increased with increasing BMI case women married in the opposite of a spinster. Conclusion: Upper BMI was inversely associated with HDL and TG in the benefit of a spinster. Although the association between BMI and both HDL and TG may be explained by oral contraceptives causing a decrease in Apoprotein, cholesterol, HDL, triglycerides the case of married women. In contrast, our findings are in conformity with the similar studies which advised the positive relationship between BMI and triglycerides related to lower HDL cholesterol and its relationship to lipoprotein lipase activity.