Biomedical Research

- Biomedical Research (2012) Volume 23, Issue 2

Surgical treatment of hydrosalpinx improves the expressions of integrin ?v?3 and L-selectin ligand in the endometrium in implantation window

Clinical importance of the improved expressions of integrin αvβ3 and L-selectin ligand in the endometrium following the surgical treatment for hydrosalpinx has been studied. A total of 60 patients with hydrosalpinx and 30 patients with fallopian tube obstruction were recruited. In the implantation window, immnohistochemistry was carried out to detect the expressions of integrin αvβ3 and L-selectin ligand in the endometrium of the hydrosalpinx patients before and after surgery and of patients with fallopian tube obstruction. In the implantation window, the expressions of integrin αvβ3 and L-selectin ligand in the endometrium of hydrosalpinx patients before surgery were significantly lower than those in patients with fallopian tube obstruction (P<0.05). However, there were no marked differences in the expressions of integrin αvβ3 and L-selectin ligand in the implantation window between hydrosalpinx patients after surgical intervention and fallopian tube obstruction patients (P>0.05). Furthermore, for patients with hydrosalpinx, the expressions of integrin αvβ3 and L-selectin ligand in the implantation window were dramatically increased after surgery (P<0.05). Hydrosalpinx decreases the expressions of integrin αvβ3 and L-selectin ligand in the endometrium in implantation window, and integrin αvβ3 and L-selectin ligand may be important factors influencing the endometrial receptivity of hydrosalpinx patients. Surgical treatment for hydrosalpinx can improve the expressions of integrin αvβ3 and Lselectin ligand in the endometrium in implantation window.

Author(s): Yiping Zhong, Jin Li, Haitao Wu, Ying Ying, Yafeng Liu, Canquan Zhou, Yanwen Xu, Xiaoting Shen, Quan Qi

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