Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 0, Issue 0

Studies on the expression and relationship between MMP-9 and EGFR in laryngeal squamous cell carcinoma

Objective: To discuss the expression and relationship between matrix metalloproteinase-9 and epidermal growth factor receptor in laryngeal squamous cell carcinoma.

Methods: Using the method of immunohistochemical to detect the matrix metalloproteinase-9 (MMP-9) and epithelial growth factor receptor (EGFR) in 58 cases of laryngeal squamous carcinoma tissues and 16 cases of normal laryngeal tissues of expression.

Results: MMP-9 in 58 cases of laryngeal squamous carcinoma tissue and EGFR positive expression rate is 68.9% and 77.6%, respectively, significantly higher than 16 cases of normal laryngeal tissue (P<0.05). MMP-9 and the expression of EGFR and tumour TNM stages, differentiate degree and lymph node metastasis (P<0.05). MMP-9, and the expression of EGFR was positively related to (chi-square=6.68, r=6.68, P<0.05). MMP-9 and EGFR is closely related to the prognosis of patients (P<0.05).

Conclusion: The expression of EGFR and the level of the expression of MMP-9 can be used as judgment index of laryngeal squamous carcinoma, malignant degree and prognosis.

Author(s): Detao Ding

Abstract Full Text PDF