A total of 198 patients of various bone disorders like osteoporosis, chronic renal failure, fractures and bone malignancy attending the OPD between October 2002 to May 2005 at Dr. D.Y. Patil Medical College, Hospital and Research Centre and Command Hospital, Pune were selected for the study. Assessment of the basal serum levels of biochemical markers like Tartarate resistant acid phosphatase (TrACP), Malondialdehyde (MDA), Alkaline phosphatase, free calcium (Ca++), Inorganic phosphorus (Pi), Superoxide dismutase (SOD) and erythrocyte reduced glu-tathione (GSH) was done. Then, the patients were divided into groups A (Vitamin E- Evinal 400 mg), B (Vitamin C- Celin 500 mg) and C (E+C) for administering antioxidants over a period of 90 days. Biochemical markers were reassessed in all the groups after 45 and 90 days of supplementa-tion. The results revealed that after 90 days supplementation there was significant reduction in serum MDA and serum ALP as compared to basal levels (p<0.001) in all three groups. Serum SOD and erythrocyte GSH showed significant increases compared to basal level (p<0.001 ) in all three groups . Serum TrACP was significantly reduced in group A and B (p<0.001) as compared to basal levels. Serum free calcium and phosphorus were unaltered. To conclude antioxidant vitamins E and C individually or conjointly improve bone meta-bolic status in skeletal disorders.