Journal of Clinical Endocrionology Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Journal of Clinical Endocrionology Research (2018) Volume 1, Issue 1

Risk factors for lymph node recurrence in papillary thyroid carcinoma:experience with 2,000 patients operated on by a single surgeon.

Background: This study determined the predictive factors affecting lymph node recurrence in a large cohort with papillary thyroid carcinoma operated on by a single surgeon.

Methods: Retrospective, cross-sectional study including 2,112 patients with papillary thyroid carcinoma undergoing total thyroidectomy and therapeutic lymph node dissection.

Results: During a mean follow-up of 41 months, 63 patients experienced lymph node recurrence. On multivariate analysis, lymph node recurrence was associated with lymph node metastases (odds ratio [OR] 19.205 for metastasis to a single lymph node, p<0.001), use of radioiodine therapy (OR 3.344, p=0.012), and extrathyroidal extension (OR 2.167, p=0.011). The presence of two positive lymph nodes (OR 18.9, p<0.001) and a primary tumor size of 1.15 cm were predictors of lymph node recurrence.

Conclusions: In a large cohort with papillary thyroid carcinoma, the presence of two positive lymph nodes and a primary tumor size of 1.15 cm predicted lymph node recurrence.

Author(s): Celso UM Friguglietti, Chin S. Lin

Abstract Full Text PDF