Biomedical Research

Case Report - Biomedical Research (2017) Volume 28, Issue 21

Retroperitoneal giant cell-type malignant fibrous histiocytoma in a young adult: A case report and literature review

Malignant Fibrous Histiocytoma (MFH) is the most common type of soft tissue sarcoma of mesenchymal origin in adults, which mainly occurs in the extremities (68%), trunk (16%) and retroperitoneum (16%), but rarely arises in the chest wall. Here, we reported a 23 y old male patient diagnosed with retroperitoneal giant cell-type malignant fibrous histiocytoma. On physical examination, tenderness was found at the left lower abdomen and periumbilical abdominal. Laboratory assessments showed that the levels of Alpha Fetoprotein (AFP), Carcinoembryonicantigen (CEA) and Carbohydrate Antigen 199 (CA199) were normal. Blood routine examination and chest CT scan were also normal. Abdominal CT scan showed there was a peritoneal huge solid mass with irregular and unaverage density shadow, which was upper to liver and downward to pelvic cavity. Enhanced CT scan revealed a ring-enhancement in solid mass. Immunohistochemical assays revealed that MFH was derived from giant cell. Positive staining of AAT, CD68, vimentin, Ki-67 and negative staining of CK were observed in the tumor tissues. Although the patient didn’t receive radiotherapy and chemotherapy, he was still alive 33 month after surgery.

Author(s): Feifei Lv, Junquan Zheng, Dexi Li, Xudong Liu, Haiping Zhao

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