It has been stated that changes in skin coloration may accompany inflammatory reaction. In this context, the purpose of this case report is to present a patient of the Igbo ethnic group in South- Eastern Nigeria with reference to his developing malignant melanoma in a long standing leg ulcer. Hitherto, the association had been mainly that of squamous carcinoma. As for prevention, research in developed countries must show the way. Meanwhile, simple ulcer management and health education are indicated.