The successful therapeutic management of generalized demodicosis depends on the early diagnosis of disease, opted treatment protocol and the client education. Diagnosis of the demodicosis is done by examination of the skin scrapings, trichogram study and biopsy procedures. Deep skin scrapings are best for the confirmatory diagnosis, trichogram is advisable where scrapings are unable to collect like peri-ocular, inter-digital space and skin folds. While collecting the scrapings, squeezing the skin increases the positive test results. Education of the owner starts from the visualization of live mite under microscope, explanation about the life cycle of mites, transmission to the other animals and humans, course of the disease, symptoms, duration of treatment and cost of medicines, follow-up visits, frequent skin scrapings examinations, immunity of the dog, revisits after complete clinical cure, breeding of the dogs and its zoonotic importance.