Journal of Gastroenterology and Digestive Diseases

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Letter to Editor - Journal of Gastroenterology and Digestive Diseases (2016) Volume 1, Issue 1

HER2 Status Examination of Biopsy Specimens from Gastric Mucosa

ERBB2 (also called HER2) is a 185 kDa transmembrane tyrosine kinase receptor. Overexpression as a result of HER2 gene amplification on chromosome 17q11.2-q12 has been observed in solid tumors including gastric and breast cancers1. HER2 is amplified in 7%-20% of gastric cancers2-5. Overexpressed HER2 is a therapeutic target of Trastuzumab, a humanized monoclonal antibody that binds to the extracellular juxtamembrane domain of ERBB2 and inhibits the proliferation and survival of HER2-overexpressing cancer cells6 (Figure 1).

Author(s): Ooi Akishi

Abstract Full Text PDF