Biomedical Research

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Expression and prognostic value of MIR-610 in patients with colorectal cancer

Background: MIR-610 has been identified as a tumor suppressor in colorectal cancer (CRC). However, its prognostic value in colorectal cancer remains unclear. The aim of this study was to explore the significance of miR-610 expression in prognosis of colorectal cancer.

Methods: The expression of MIR-610 was determined in 209 pairs of CRC samples and the corresponding surrounding non-tumor tissues by Quantitative RT-PCR. Then, the association of miR-610 expression with clinicopathological factors and the prognosis of colorectal cancer patients were also analysed.

Results: The expression of MIR-610 was significantly down regulated in colorectal cancer when compared to the non-tumorous tissues (p<0.001). Low level of miR-610 was obviously related to large tumor size, positive lymph node metastasis, and advanced clinical stage. Moreover, Kaplan-Meier survival analysis showed that the overall survival rate of the low miR-610 expression group was significantly lower than that of the high miR-610 expression group (p<0.001). The multivariate analysis identified low MIR-154 expression as an independent predictor of poor survival.

Conclusions: MIR-610 may play an important role in the progression of colorectal cancer, and could be used as an independent prognostic biomarker for patients with colorectal cancer.

Author(s): Feng Shi, Rumin Li, Ping Guo