Biomedical Research

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Expression and its correlation with metabolic syndrome of protein tyrosine phosphatase 1B in serum of polycystic ovary syndrome patients

Objective: To investigate the expression of protein tyrosine phosphatase 1B (PTP1B) in serum of Polycystic Ovary Syndrome (PCOS) patients and its correlation with the Metabolic Syndrome (MS).

Methods: ELISA was used to detect the expression of protein tyrosine phosphatase 1B (PTP1B) in the serum. Samples were divided into three different groups: 21 cases in control group; 48 cases in the group of non-MS-PCOS; 15 cases in the group of MS-PCOS.

Results: The level of PTP1B in serum of PCOS patients was (66.65 ± 24.30 ng/L) higher than that of control group (52.72 ± 16.20 ng/L),(P<0.05). PTP1B level in serum of MS-PCOS was (73.14 ± 20.07 ng/L) that was higher than that of non-MS-PCOS (64.62 ± 25.33 ng/L, P<0.05). PTP1B was positively correlated with Body Mass Index (BMI), Waist Circumference (WC), Fasting Plasma Glucose (FPG) and homeostatic model assessment insulin resistance (HOMA-IR (P<0.05)).

Conclusion: Elevated serum level of PTP1B is an important factor which caused insulin resistance in PCOS patients. Moreover, PTP1B is related to obese, fasting plasma glucose and insulin resistance of metabolic syndrome, which may play a role in the diagnosis or treatment of PCOS and metabolic syndrome.

Author(s): Xuecheng Shao, Jia Li, Yu Wang, Qian Liang, Shurong Song