Biomedical Research

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Expression and clinical significance of long non-coding RNA HOTAIR in endometrial carcinoma

This study aimed to investigate the expression and clinical significance of HOX Transcript Antisense RNA (HOTAIR) in endometrial carcinoma, and discuss its correlation with transforming growth factor- β1 (TGF-β1) in EC tissue. Sixty patients with EC were enrolled. The EC tissue and cancer adjacent tissue (control) were collected. The expressions of HOTAIR and TGF-β1 mRNA in EC and adjacent tissue were determined using real-time quantitative PCR. Results showed that, the relative expression levels of HOTAIR and TGF-β1 mRNA in EC tissue were significantly higher than those in adjacent tissue (P<0.05). The expression of HOTAIR mRNA was significantly correlated with pathological grade, muscular invasion depth and clinical stage of EC (P<0.05), and that of TGF-β1 mRNA was significantly correlated with muscular invasion depth and clinical stage of EC (P<0.05). In EC tissue the expressions of HOTAIR and TGF-β1 mRNA were positively correlated (r=0.676, P<0.05). There was significant difference of overall survival of patients between high and low HOTAIR expression groups (χ2=4.346, P<0.05). The abnormal expression of HOTAIR may be involved in the occurrence and development of EC. The expression of HOTAIR is positively correlated with TGF-β1 expression in EC tissue.

Author(s): Yanhua Zhang, Qinghua Zhang, Shumei Tuo, Xiaoli Wang, Yan Wang, Shengju Hao, Jing Zheng, Bingxin Cai