Biomedical Research

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Effect of super-early operation on treatment of high-grade ruptured intracranial aneurysm

Objective: To explore the feasibility and clinic value of super-early operation in treatment of high-grade intracranial aneurysm with ruptured hemorrhage.

Methods: From August, 2014 to March, 2016, 46 patients suffering high-grade ruptured intracranial aneurysm were collected. Among them, 23 patients were treated with early operation (operation within 48 or 72 h, group A) while the rest received super-early operation (operation within 24, group B). The differences of effect, post-operation complication, and recovery between groups A and group B were analysed statistically with chi-squire test.

Results: Compare to the 30.43% aneurysms rupture recurrence rate in patients who received early operation (group A), the recurrence rate of aneurysms rupture in patients receiving super-early operation (group B) is lower to 4.35%. Additionally, the post-operation complication rate of group B (8.69%) is significantly lower than that of group A (39.13%). Consistently, 18 out 23 patients in group B recovered very well from the operation, while only 10 out 23 patients in group achieved good recovery.

Conclusion: Super-early operation has certain clinical application value in treatment of high-grade ruptured intracranial aneurysm.

Author(s): Zhenbo Liu, Liguo Qi, Jian Zhu