Biomedical Research

- Biomedical Research (2010) Volume 21, Issue 3

Effect of addition of intrathecal midazolam to 0.5 % Bupivacaine on duration of analgesia

The Objectives were to compare the mean period of analgesia for intrathecal Midazolam 0.5 ml plus bupivacaine and bupivacaine alone and to monitor the side effects of intrathecal Midazolam (0.5 ml) plus bupivacaine and bupivacaine alone. A comparative study was carried out to evaluate the analgesic efficacy and side effects of intrathecal Midazolam along with 0.5% Bupivacaine in 80 ASA I and II patients, aged 16 – 60 years, undergoing surgeries below umbilicus, elective as well as emergency. They were randomly divided into two groups of 40 each (n=40). Group I (control): received Bupivacaine 0.5% heavy 3 ml + NS 0.5 ml and Group II (study): received Bupivacaine 0.5% heavy 3 ml + Midazolam 0.5 ml. All patients were haemodynamically stable and there were no serious side effects in any of the patients in both the groups. The mean duration of sensory analgesia in group I and II was 76.30 ± 6.05 minutes and 299.25 ± 15.75 minutes respectively. The difference in the mean duration of sensory analgesia in both the groups was statistically significant. (P < 0.01)

Author(s): Shirish Chavan, Sachin Mumbare, Manisha Mane

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