Biomedical Research

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Dysregulated pathways in type 2 diabetes mellitus

Objective: Type 2 Diabetes Mellitus (T2DM) is a leading health problem worldwide. In this study, we aimed to identify the pathways significantly relevant to T2DM, and a brief review based on these pathways was made.

Materials and Methods: The genes associated with T2DM were extracted by text mining tool from literature database. Then we employed the Fisher’s exact test based on the cumulative hypergeometric distribution to evaluate the pathways relevant to T2DM.

Result: A total of 135 genes associated with T2DM were confirmed and 76 pathways significantly relevant to T2DM were identified from 880 cellular pathways. These 76 pathways could be classified mainly in five classes: adipocytokine, inflame, PPAR, insulin and T2DM pathway. Adipocytokine pathway from KEGG database was the most relevant pathway.

Conclusion: Disregulation of adipocytokine and inflammatory pathway is the hallmark of T2DM originated from the organism in the status of excess energy over long time span.

Author(s): Li H, Li H, Ran J, Mao X