Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 22

Comparison of short- and long-term therapeutic effects of laparoscopic and open-type hepatectomy for primary hepatic carcinoma

Objective: To compare short- and long-term therapeutic effects of laparoscopic and open-type hepatectomy for primary hepatic carcinoma.

Method: Forty patients with primary hepatic carcinoma in our hospital were recruited from January 2013 to August 2014. They were divided into two groups, namely, laparoscopic and open-type, with 20 cases in each group, and their short- and long-term therapeutic effects were then compared.

Results: Intra-operative bleeding quantity, length of operative incision, extubation time, eating time, and length of stay in the laparoscopic group were lesser than those in the open-type group; operation time was more than that in the open-type group (P<0.05). Comparative differences in pre-operative liver functions, such as Aspartate Transaminase (AST) and Alanine Transaminase (ALT), between the two groups did not have statistical significance (P>0.05). Three days after the operation, AST and ALT levels of both groups increased to peak values (P<0.05). However, 10 days after operation, the decrease in AST and ALT levels was obviously faster in the laparoscopic group than in the open-type group (P<0.05); the occurrence rate of post-operative complications was obviously lesser in the laparoscopic group than in the open-type group (P<0.05); comparative differences in three-year recurrence and survival rates between the two groups did not have statistical significance (P>0.05).

Conclusion: Laparoscopic hepatectomy provided several advantages, such as small trauma, minor influence on liver function, and few post-operative complications, for patients with primary hepatic carcinoma; however, its post-operative three-year survival rate was equivalent to that of open-type operation, indicating its high therapeutic value.

Author(s): Kun He, Ze-Min Hu, Jia-Hou Ruan, Dong-Dong Huang, Xue-Yi Gong, Qi-Jie Luo

Abstract Full Text PDF