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Chronic toxicity of Chenopodium ambrosioides in rats

The aqueous leaf extract, after six weeks administration showed a decrease in weight of the treated animals, whereas body weight of the un-treated animals rose progressively as the period increased. Phytochemical screening of the plant reveals the presence of saponins, alkaloids and volatile oils. Pathological features like congestion of the lungs, metaplastic changes in the mucosal surface of the stomach, and necrosis of the kidney tubules were noticed.

These abnormalities may possibly not develop with C. ambrosioides used for a short period.

Author(s): O.O. Amole and M.C. Izegbu