The search of literature showed Urolithiasis as a multifactorial recurrent disease, distributed worldwide in urban, rural , non industrial and industrial regions with different chemical composition of analyzed stones in context to various etiological and risk factors. The present study was aimed to qualitatively analyze the uroliths obtained by surgical intervention at Krishna hospital Karad, a South West region in Maharashtra (India), to evaluate the predominant constituent present in them and report its significance. The study reported, urolithiasis was more suffered by individuals between the age group of 30 to 60 years with more predominance in males than females. The chemical analysis of uroliths showed that all the assessed stones were of mixed heterogeneous type, Magnesium Ammonium Phosphate (71.2%) was predominant constituent followed by Calcium Oxalate (68.8%), Calcium Carbonate (64.0%), Urate (44.8%), Cystine (12.8%), Xanthine (2.4%) and Fibrin (1.6%). The study concludes simple qualitative laboratory based method for assessing chemical composition of various uroliths allowed a reliable diagnosis of stone contents whose data may be useful in advising the people of this region for taking preventive measures for reducing the risk of prevalence and recurrence of urolithiasis in them.