Neonatal intestinal obstruction is an acute emergency with varied etiologies. Neonatal intussusception is extremely rare. We report the case of a female preterm newborn, diagnosed with acute intussusception. She presented with abdominal distension and signs of intestinal obstruction. The clinical findings showed an intussusception at the ileocolic junction. Contrast enema was performed successfully to reduce the intussusception with success.