Surgical site infection (SSI) is one of the most common infections in the health care settings with high financial burden and mortality rate.112 patients with infection of SSI were identified. 40 patients without SSI served as control group. Diabetes status, History of smoking, alcohol, other therapy before surgery is the main factors for potential risk of acquiring SSI. The SSI was studied from the day patient underwent surgery. Out of 88 patients (47 male and 41 female) with mean, age 45 ± 2.5 years. 42 (47.7%) patients had SSI at early stage and 46 (52.3 %) at later stage with mean duration of the hospital stay 287 ± 57 days. Among 40 controls, group (24 male and 16 female) with mean age 51 ± 4.5 years. Only 18 (45%) developed SSI. Microbiological profile of the SSI also studied both in study and control group patients. 18 (20.5%) patients implants were removed. 20 (47.6%) patients received β- lactam drugs. 24 (52.2%) patients underwent debridement. 12 (26.1%) received suppression therapy with antibiotics. In control group patients 5 (27.8%) patients implants removed. 6 (54.5%) patients received antibiotic therapy with Amikacin and cefozolin. 5 (27.3%) patients underwent surgical debridement. Control of diabetic status and reducing hospital stay before and after surgery with higher antibiotic prophylaxis can lead to decreased SSI, which in turn will reduce the financial burden of the patients after surgery.