Biomedical Research

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A new supramolecular Zinc (II) complex for inhibiting human osteoma sarcomatosum cells growth

A two-fold interpenetrating porous metal-organic framework, namely {[Zn(bpydb)H2O](DMA)12]}n (1, bpydbH2=4,4´-(4,4´-bipyridine-2,6-diyl) dibenzoic acid, DMA=N,N-Dimethylacetamide) based on a π- electron-rich ligand has been solvothermally prepared and characterized by single-crystal X-ray diffraction analysis. This compound is a 2-fold interinfiltrating configuration that has a great solventaccessible volume. The reseason to search on the antitumor activities of the title compound 1 and its corresponding organic ligand bpydbH2 was to inhibit human osteoma sarcomatosum cells (293T, 3T3, B16 and 769-P) developed by MTT assay. It was concluded that by the comparison with the organic ligand, compound 1 exerted rather potent activities against all of these cell lines.

Author(s): Gui Chen, Lu Gao