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A new look of gastric cancer from epidemiology to clinical management.

Gastric cancer (GC) is the fourth most common cancer and the third leading cause of cancerrelated death worldwide. Recent advance in diagnosis and treatment has improved longterm survival for patients with early GC, yet the survival rate for advanced cancer patients is still poor. This article reviews the current epidemiology and different risk factors, such as environmental challenges, gene polymorphism and epigenetic profiles. It also introduces the clinical management against these risk factors and repurposes the new clinical application of vitamin D for the prevention and treatment of GC in humans.

Author(s): MX Li, J Shen, ZG Xiao, L Zhang, X Wu, CH Cho