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A comparative study of the effect of metoral and magnesium prophylactic in controlling atrial fibrillation after coronary arteries bypass operation

Objective: Arterial fibrillation is the most common type of arrhythmia observed after coronary arteries bypass operation and culminates in hemodynamic instability, higher morbidity and mortality rate, longer period of hospitalization, and higher hospital expenditures. The present research seeks to compare the effect of metoral, magnesium prophylactic, and a mixture of both (magnesium and metoral) in reducing the occurrence of CABG (coronary arteries bypass graft).

Methods: This is a double blind clinical trial where 195 patients candidated for CABG were selected based upon exclusion and inclusion criteria and randomly divided into three groups of metoral (receiving 5 mg metoral), magnesium (receiving 1.5 g magnesium), and combined (2.5 mg metoral+1 g magnesium). The resulting information was then analyzed using SPSS v.19 and ANOVA statistical tests.

Results: A significant difference was observed between the three groups in terms of post-operation AF and other types of arrhythmia. Higher rates of post-operation AF were observed in magnesium group than the two other groups (P=0.001). On the other hand, higher rates of post-operation AF were observed in the combined group than what was observed in metoral group (0% vs. 4.5%). The occurrence of other types of post-operation arrhythmia in the combined group was more than what was observed in the other two groups (P=0.001).

Conclusion: Both metoral and magnesium are really useful in reducing post-operation AF among the patients with CABG, while metoral was more effective than magnesium. On the other hand, adding magnesium to metoral can clearly enhance its prophylactic effects.

Author(s): Alireza Kamali, Azadeh Hosseini, Mehrzad Sharifi, Shirin Pazuki