Adenotonsillectomy is the most common of head and neck surgeries, which is mainly done on patients up to 15 y old. Non-narcotic intravenous anesthetics are widely used to facilitate rapid induction of anesthesia or to provide sedation through the MAC in the Intensive Care Unit (ICU). Propofol and sodium thiopenthal are drugs widely used for induction of anesthesia. Emergence Agitation (EA) is one of the most common problems in pediatric patients especially after recovery of anesthesia maintained by volatile anesthetics such as isoflurane. Agitation is defined as a series of physical symptoms or emotional distress that involves the following symptoms separately or in combination: crying, restlessness, coughing, oral manifestations and irrational behaviors. In this study, we aim to demonstrate the effect of Propofol and thiopental sodium on transient agitation isoflurane iodine in adeno-tonsillectomy during recovery time. 40 individuals were enrolled to this project. Analysis showed that using propofol could significantly decrease MOPS score in 4 and 6 h later of the surgery (P<0.05). In addition, it showed that propofol induced lower incidence of agitation in 6 h later in compare to thiopental (P<0.05). However, analysis failed to show any significant difference between 0.25, 0.5, 2 and 4 h later to the surgery. In conclusion, we showed that propofol could decrease the severity and incidence of EA in pediatrics as well as the MOPS score in compare to thiopental at 4 to 6 h after surgery in the recovery room.