Asian Journal of Biomedical and Pharmaceutical Sciences

Asian Journal of Biomedical and Pharmaceutical Sciences 44 7897 074717

Pharmacogenetics New Findings

Adverse drug reactions (ADRs) are one of the important reasons of patient morbidity and mortality. Pharmacogenomics is observing of ways person reaction to tablets is laid low with genetic mutations on the genome level. There is clinical evidence that polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters and drug targets can cause the incidence of Adverse drug reactions. In addition, mutations of positive genes can precipitate Adverse drug reactions. Over the beyond years, genome wide association studies (GWAS) have identified a range of commonplace and uncommon variants that are associated with increased danger of Adverse drug reactions. As low priced and reliable genetic testing equipment become to be had to physicians, pharmascogenomics looks promising to facilitate individualization of drug therapy and as a result, this can maximize the healing efficacy of medication in sufferers even as minimizing the prevalence of Adverse drug reactions. Shu-Feng Zhou, Pharmacogenomics-Guided Approaches to Avoiding Adverse Drug Reactions.

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