Journal of Genetics and Molecular Biology

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Journal of Genetics and Molecular Biology 44 7897 074717

Hereditary Spastic Paraplegia Research Articles

A person with HSP is probably going to possess inherited an abnormal gene from their parents that causes the long nerves in their spine to deteriorate. These nerves control voluntary movement. This means that muscles within the lower body don't receive the right messages telling them to relax or contract. It leads to spasticity and weakness in the leg muscles, which progressively gets worse. Most forms of HSP mainly affect the lower body – the arms and hands are usually unaffected. On average, the symptoms of HSP start in mid-adulthood, although it can start as late as age 70 or in young children. Reflexes become exaggerated, and leg cramps, twitches, and spasms occur, making leg movements stiff and jerky.

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