Journal of Clinical Immunology Research

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Drug Distribution

The process of transferring a drug from the bloodstream to tissues is observed as distribution. a similar principles that govern drug absorption (e.g. ionization of a drug, lipophillicity of a drug, size of a drug, pH of the atmosphere, etc.) also govern the rate and extent that a drug can distribute to numerous tissues within the body. additionally, there are further factors at play, significantly non-specific binding to proteins.

Commonly, drugs bind non-specifically to albumin within the plasma. in addition, one drug, digoxin, tends to bind non-specifically to skeletal muscle, when, in fact, its desired actions occur within the heart. once drugs bind non-specifically to proteins, their movement is restricted. that's because the big proteins to that they're certain won't be able to readily distribute to different parts of the body. The protein acts as a “reservoir” of kinds.  As long as a drug is certain non-specifically to a protein, it cannot have a therapeutic action, nor will it's eliminated (metabolized hepatically by the liver or excreted by the kidneys).

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