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Synthesis of borono-fluoro-deoxy-D-glucose as boron carrier for Boron Neutron Capture Therapy (BNCT)
Global Summit on Biopharma & Biotherapeutics
May 14-15, 2018 | Montreal, Canada
Hulya Ozdemir, Zafer Akan, Taner Ozel and Gokhan Oto
Van Yuzuncu Yil University, Turkey
Posters & Accepted Abstracts : Asian J Biomed Pharmaceut Sci
Abstract:
Objective: The 18F-labeled Deoxy-D-Glucose exhibits high affinity to cancer tissue as a PET (Positron Emition Tomography) imaging agent for metastatic cancers. Complexation of 10B to 18F-DG complex may create a useful BNCT (Boron Neutron Capture Therapy) agent for cancer therapy. In previous studies, complexation and characterization of 10B with DG was evaluated and bio distribution analysis was completed successfully. Radio labelled 10B-DG will be useful approach for uses for BNCT applications. Methods: The 18F-DG synthesized by ion exchange and complexed with 10B(OH)3 via pH reactions. 18F-DG-10B complexation was assayed with Agilent 1260 Infinity HPLC DAD and Agilent 6420 Triple Quad LC/MS. Complexed molecule defragmented and fragmentation products assayed with Agilent 6420 Triple Quad LC/MS for confirmation. Results: 10B-18F-DG complex was obtained with ionexchange pH reaction successfully. Complexation of two 10B(OH)3 to 18F-DG was determined with Triple Quad LC/ MS. Purification of 10B-18F-DG is currently in progress. Conclusions: Radio-labelled 10B will supply new insight to research for BNCT studies. Cancer detection and therapy will be applicable in same schedule with 10B-18F-DG complex e: hulyaozdemir39@gmail.com
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