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Phyto-formulations for Matrix Metalloproteinases (MMPs): Novel targets in UV radiation induced skin Carcinoma
2nd International Conference and Exhibition on Pharmaceutics and Advanced Drug Delivery Systems
July 05-06, 2019 | Paris, France
Swarnlata Saraf
Pt Ravishankar Shukla University, India
Scientific Tracks Abstracts : Asian J Biomed Pharmaceut Sci
Abstract:
The continuous exposure of skin to ultraviolet radiations generates reactive oxygen species leading to photoaging that causes degradation of dermal collagen and degeneration of elastic fibers. These fibres provide mechanical strength to the skin. In order to maintain the appearance of the skin, a complete understanding of the mechanism behind skin cellular degradation is desired, so that a better cosmetic formulation can be formulated. The studies have been shown that macrophages are crucially involved in skin Carcinoma and express significantly higher levels of M1 (CD40, CD127) and M2 (arginase I) markers as well as higher levels of MMP-9, a pivotal enzyme in cancerous matrix remodeling and cancerous invasion, than macrophages from the basal cell carcinomas. These macrophages represent different receptors like folic acid receptors which was exploited to know the extent of efficacy for delivery of phyto-formulations containing nanoparticles, transferosomes, liposomes etc. to cure carcinoma. The flavanoidal rich natural bioactives have been extensively incorporated in a suitable base and have proven their potential as a topical photoprotectants but their activity remained restricted due to poor solubility profile. Now researchers are working to design the Novel Targeted formulations to deliver these natural flavanoidal drugs to improve its efficacy and ultimately skin properties. In current years, the focus area of work is on some traditionally used bioactive moieties as natural matrix metalloproteinases inhibitors (MMPIs) and emphasized on more extensive and specific studies, so that a good combination of natural as well as synthetic MMPIs with the conventional drugs can be used for treating UV radiations induced ailments.
Biography:
Swarnlata Saraf is serving as a Professor at Pt Ravishankar Shukla University, India since last 14 years. Her field of specialization is Pharmaceutics and Research area of interest includes herbal formulations, drug delivery and exploring targeting aspects of novel phyto-formulations. She has expertise in developing phyto-formulations and passion in improving wellbeing of the society. She gains this experience by continuous and consistent efforts of her work in cosmetic and drug delivery laboratories in the institute. she is associated with many national apex bodies like NAAC, UGC, PCI, AICTE, and CRS as member and as an expert in different committees. She also served as an expert of grant evaluator of Israel Science Foundation. She Innovated Technology for Value edition to existing herbs in Chhattisgarh & engaged in promotional activities like Promotion of Janaushadi Kendra by dept. of family welfare, Govt. of India, Regular interaction with pharmacists. She is also Involved in awareness programmes through Shakti-Vigyan Bharati relating to health & hygiene, Sustainable development and education for women, Regular activities are organized for public awareness.
E-mail: swarnlatasaraf@gmail.com
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