NEUROMETABOLIC EVIDENCES FOR DIABETES AND INTERMITTENT EXPLOSIVE DISORDER: A CASE REPORT
2nd Global Summit on IMMUNOLOGY AND CANCER THERAPY
May 22-23, 2019 | Rome, Italy
Ahmet Mithat Tavli
Istanbul University, Turkey
Scientific Tracks Abstracts : Immunol Case Rep
Background: Despite studies suggesting that increased insulin resistance and higher fasting glucose levels
may secondary lead to glucose hypo metabolism in specific brain regions which may contribute to the development
of cognitive disturbances during diabetes I-II, the underlying mechanism of diabetes associated impulse
control disorders is still unclear. Interestingly, a very recent study has demonstrated that impulse control
disorders (especially intermittent explosive disorder) were significantly associated with the diabetes diagnosis.
Thus, studies have reported that intermittent explosive disorder and borderline personality are associated with
an increase of glucose metabolism in the limbic system and a decrease in prefrontal regions supporting the
role of dynamically interacting cortico-subcortical networks. Besides their key role as a pacemaker for cortical
centres via purely motoric coordination, lentiform nucleus and pons have been also shown to play a significant
role in emotional process in also involving reflexive emotional reactions. This is in line with previous evidences
showing that gray matter volume reductions in neocortical regions may be specific to psychiatric disorders.
These findings together suggest that a disturbance in connectivity between different brain regions, rather
than abnormalities within the separate regions themselves may be responsible for the clinical symptoms of
intermittent explosive disorder.
Case: Here author describe a 36 year old man, experience the aggressive outburst symptoms one year after he was diagnosed as type II DM.
Ahmet Mithat Tavli completed his PhD in Selçuk University, Turkey. He is the Director of Neurology Department of Milas Government Hospital, Turkey. He studied for two years in Florance Nightingale Hospital and studied for two years in Medipol Experimental Laboratory in İstanbul. He has over 20 publications in various journals.
E-mail: [email protected]