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MOLAR CONCENTRATION WELCOMES AVOGADRO IN POSTGENOMIC ANALYSIS
Joint Event on International Conference on PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS & 19th International Conference on CELLULAR AND MOLECULAR MEDICINE & 19th Annual Congress on PSYCHIATRY AND PSYCHIATRIC DISORDERS
October 19-20 , 2018 | Tokyo , Japan
Archakov A I
Institute of Biomedical Chemistry Russian Federation
Keynote : Asian J Biomed Pharmaceut Sci
Abstract:
The researchers working with high-throughput methods of genomics, transcriptomics, and proteomics reconsider the concept of concentration and evaluate the data obtained in the number of copies of biomacromolecules. Measurement of copy number reflects a steady trend in increasing the sensitivity of postgenomic analytical methods, up to the level of a single molecule. In this paper we review the physical meaning of the terms “molar concentration” and “Avogadro’s number” to establish a relationship between them. The relationship between the molar concentration and the number of copies of that same macromolecule in a certain volume is set through the reverse Avogadro’s number, the value of which (≈10-24 М) characterizes the molar concentration of a single molecule in one liter. Using the reverse Avogadro’s number, we deal with situations in analyzing homogeneous biological solutions and heterogeneous cellular material.
Biography:
Archakov A I Scientific Advisor of Institute of Biomedical Chemistry, was born January 10, 1940, in Kashin, Kalinin (Tver) region – scientist, biochemist. A.I. Archakov had organized a scientific school to study molecular organization and functioning of oxygenase cytochrome P450-containing systems, molecular mechanisms of the structure and function of membranes and biological oxidation. Under the guidance of A. I. Archakov, the institute’s members have developed a fundamentally new pharmaceutical composition “Phosphogliv” with antiviral activity for the treatment of liver diseases of various etiology. A.I. Archakov’s present-day/ current areas of expertise relate to research in the field of post-genomic technologies, nanobiotechnologies, proteomics, development of approaches to create personalized medicine of the future. A.I. Archakov is the pioneer in the development of proteomics in Russia. Currently, he is the international “Human proteome” project coordinator in Russia/ the coordinator representing Russia in the international “HP” project
E-mail: inst@ibmc.msk.ru
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