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Malignant hyperthermia: Possible diagnostic tool by electromyography
Joint Event on 3rd International Conference on Food Science & Technology & World Congress on Biotechnology & Medical Microbiology
October 25-26, 2018 | Frankfurt, Germany
Charles H Williams
The Williams Research Laboratory, USA
Posters & Accepted Abstracts : J Biotech and Phyto
Abstract:
The evaluation of the action potential at the myoneural junction in several muscles of the Malignant Hyperthermia susceptible pig shows that the amplitude of the action potential voltage is increased dramatically at the myoneural junction. The duration of the amplitude of the action potential is also significantly increased.These data, along with our other findings lead us to develop a hypothesis that the sodium channels at the myoneural junction were leaky in that they did not close as quickly as normal pig sodium channels and thereby allow an influx of sodium ions into muscle cells that had to be pumped out by the Na-K ATPase. The pumping is an energetic process that requires the expenditure of ATP energy sources and simultaneously produced heat. The flow of sodium ion into muscle cells was a concentration dependent process that dis not expend energy. We observed core temperatures up to 118oF. core temperature over 106oF are highly lethal. Other high body temperatures may be caused by the same heat generating mechanism during other disease states. The sodium channel futile cycle provides a mechanism for generation heat to maintain a normal body temperature in warm blooded animals. We would not expect to find this heat generating mechanism in cold-blooded animals.It would be nice to have a detector that would measure sodium ion flow during the action potential. The changes in sodium ions at the membrane of the muscle are designed to maintain the -90mv charge across the membrane. Loss of the membrane charge leads to a lethal situation and the death of the organism.
Biography:
E-mail:
chwilliams2135@sbcglobal.netPDF HTML