+1 (202) 780-3397
Intracellular delivery of biomacromolecules
7th World Congress on Chemistry
November 13-15, 2017 Athens, Greece
Nathalie Lavignac
University of Kent and Greenwich at Medway, United Kingdom
Posters & Accepted Abstracts : J Biotech and Phyto
Abstract:
Efficient delivery of non-permeant therapeutic agents with intracellular therapeutic targets is challenging. Over the years, methods using viral and/or non-viral vectors have been developed. Synthetic polymers, often considered a safer alternative, may be tailored to improve cytoplasmic access and modulate cell specific targeting. Poly(amidoamine)s (PAAs) are a family of synthetic functional polymers developed for use as polymer therapeutics.They are synthesized by Michael addition polymerization, are generally water soluble and display pH-dependent membrane activity. We will discuss the biological rational for the development of these polymers and review their application for the delivery of macromolecular drugs (e.g. proteins, oligonucleotides).
PDF HTML