Human c-Cbl and Cbl-b proteins are more highly expressed in the thymus compared to the testis
Joint Event on Global Summit on Immunology and Cell Biology & Global Congress on Bacteriology and Infectious Diseases
June 25-26, 2018 | Amsterdam, Netherlands
Mazo Kone, Rachida Salah and Harir Noria
Djillali Liabbes University, Algeria University of Ibadan, Nigeria
Scientific Tracks Abstracts : Virol Res J
Background & Objectives: c-Cbl and Cbl-b are two members of the Cbl family proteins, with a crucial role of downregulation of tyrosine kinase receptors. They act as E3 ubiquitin ligases and are multivalent adaptor proteins, making them important in maintaining homeostasis in the body. This study investigated the expression level in thymus and testis in normal conditions. Methods: The expression level was assessed by immunochemistry of tissue microarrays of normal thymus and testis biopsies. Results: Cbl-b and c-Cbl proteins were found to be highly expressed in normal testis and thymus, indicated as yellowish-brown granules in the cytomembrane and cytoplasm compared to controls. The c-Cbl appears to be more highly expressed than the Cbl-b in the thymus, while c-Cbl appears slightly stronger than Cbl-b in the testis. The thymus was found with a higher grade compared to testis. Conclusion: In this work, we concluded that in normal condition, thymus tissue expresses more Cbl family proteins (c-Cbl and Cbl-b) than the testis tissue in humans.
Mazo Kone received basic training in biology of cancer, physiopathology of metabolic diseases, infectious diseases and many more. However, he quickly developed an interest for the molecular biology of cancer, physiology of the cell and infectious diseases. He worked on the oncogenic properties of Human c-Cbl and Cbl-B as Master’s project work. Currently, he is doing a Ph.D in Cell Biology and Genetics at the University of Ibadan in Nigeria. His research is on congenital infections in pregnancy both in Mali and Nigeria. In general, his research works are focused on molecular biology of cancer and infectious diseases. He is the Leader of Rachetes Algeria since 2012, the promoter and the manager of The Biomedical researcher project. He is a Lecturer in Mali (Universite Scientique Libre de Bamako). He is also a writer and an author in personal development. He likes research, teaching, reading and communication.