Hormonal cascades of pregnancy: How drug delivery can regulate peri and post-partum neurogenesis and emotional outcomes among women
2nd International Conference and Exhibition on Pharmaceutics and Advanced Drug Delivery Systems
July 05-06, 2019 | Paris, France
Tabinda Hasan, Kavitha ganesh and Teseen Fatima
Princess Nourah University, KSA
Scientific Tracks Abstracts : Asian J Biomed Pharmaceut Sci
Numerous factors govern mood changes of pregnancy; like
physiological/biological changes related stress, metabolism
changes, or shifting levels of estrogen, progesterone and
Oxytocin hormones. Ovarian hormones prepare the maternal
body for successful fertilization while placental hormones
facilitate maternal adaptations to ensure optimal fetal
development and maintain pregnancy; Changes in hormone
levels can significantly affect production of neurotransmitters
that regulate mood. Every woman responds to these changes
differently. Some experience heightened emotions, while others
feel depressed or anxious. It has been generally observed that
moodiness flares around 6-10 weeks of pregnancy, eases during
second trimester, and reappears as the ‘due date’ approaches.
Prolactin stimulates nursing, Oxytocin is a ‘feel good hormone’ that stimulates maternal feelings of love and bonding for the baby while sudden variations in ‘Progesterone- Estrogen levels’ during pregnancy and after delivery have been notoriously linked to depression or anxiety. These hormone cascades are regulated by positive & negative feed-back mechanisms. In ‘sudden termination of pregnancy’ events as well as ‘extended breastfeeding’or ‘abruptly ended breast feeding’; maternal adaptations to changed hormone levels are insufficient and extreme outbursts like self-harm and even harming of the baby might occur. The maternal brain is remarkably plastic and exhibits multifaceted neural modifications. Hormone delivery mechanisms can facilitate affective neurogenesis and development of cordial neural networks. Hence, choosing and delivering ‘appropriate doses’ of ‘required hormones’ along temporally coordinated mechanisms might positively influence psycho-social and maternal and child health outcomes. This review highlights peri-partum adult neurogenes and associated mood changes with underlying hormonal mechanisms. It also elucidates the functional consequences of neurogenesis in the peripartum brain and the extent to which this process might play a role in maternal care, cognitive functions and postpartum mood. Finally, the study examines and discusses the effects of hormone dependent maternal neurogenesis on parenting styles.
Tabinda Hasan has completed her PhD at the age of 30 from Aligarh Muslim University, India. She is an Assistant Professor at Princess Nora University, Saudi Arabia. She has over 40 publications that have been cited over 200 times, and her publication H-index is 10 and she has been serving as an editorial board member of several reputed journals.
E-mail: [email protected]